| Gel-filtration of serum gamma-glutamyl-transpeptidase with HPLC in hepatobiliary diseases and its significance. | |
| | |
MedLine Citation:
|
PMID: 2903108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Serum gamma-glutamyl-transpeptidase (gamma-GTP) from patients with various hepatobiliary diseases was fractionated by molecular size using HPLC to investigate the heterogeneity of serum gamma-GTP. Serum gamma-GTP eluted with HPLC showed essentially 3 elution peaks of different molecular size. In the sera of normal patients, there was little gamma-GTP in the high molecular fraction, and most occurred in the low molecular fraction. Intermediate molecular gamma-GTP appeared only in the sera of patients with hepatobiliary disease. In the sera of patients with extrahepatic biliary obstruction, the percentage of high molecular gamma-GTP to total serum gamma-GTP activity was higher than that of other patients. High molecular gamma-GTP increased in the sera of patients with extrahepatic biliary obstruction. Intermediate molecular gamma-GTP appeared in the relatively higher molecular fraction in the sera of patients in whom alcohol consumption might have caused serum gamma-GTP increase, and in the relatively lower molecular fraction in the sera of patients with extrahepatic biliary obstruction. It was concluded, therefore, that the position of elution of intermediate molecular gamma-GTP corresponded to the morbid state. It was shown that intermediate molecular gamma-GTP appeared in the relatively low molecular fraction, corresponding to the increase of serum total bile acids concentration. |
| | |
Authors:
|
K Nishii; H Oda; K Kamisaka; S Hosaki |
Related Documents
:
|
16091078 - Serum malondialdehyde level in children infected with vampirolepis nana. 8142118 - Serum soluble interleukin-2 receptor in colorectal cancer. 22228568 - Immune-mediated diseases and immunodeficiencies associated with thymic epithelial neopl... 844218 - High level of a nerve growth factor in the serum of a patient with medullary carcinoma ... 18257808 - Darbepoetin alfa (krn321) administered intravenously once monthly maintains hemoglobin ... 12373528 - Recognition and treatment of response fluctuations in parkinson's disease: review article. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Gastroenterologia Japonica Volume: 23 ISSN: 0435-1339 ISO Abbreviation: Gastroenterol. Jpn. Publication Date: 1988 Aug |
Date Detail:
|
Created Date: 1988-11-29 Completed Date: 1988-11-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0152744 Medline TA: Gastroenterol Jpn Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 435-41 Citation Subset: IM |
Affiliation:
|
Third Department of Internal Medicine, Tokyo Medical and Dental University, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carcinoma, Hepatocellular
/
enzymology* Cholestasis, Extrahepatic / enzymology* Chromatography, Gel Chromatography, High Pressure Liquid Humans Liver Diseases, Alcoholic / enzymology* Liver Neoplasms / enzymology* gamma-Glutamyltransferase / blood*, isolation & purification |
| Chemical | |
Reg. No./Substance:
|
EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myocardial revascularization using both internal mammary arteries. Clinical results and surgical str...
Next Document: Changes of plasma insulin glucagon and somatostatin in portal blood and morphological changes of isl...