Document Detail


Gel-Phase synthesis of hydrophobic (thr14) (thr19) galanin (1 -19) fragment on a high capacity flexible crosslinked polystyrene support.
MedLine Citation:
PMID:  11763365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A hydrophobic analogue of human galanin (1-19) fragment has been synthesized using Boc/Bzl tactics to demonstrate the synthetic utility of the flexible crosslinked polystyrene support prepared by the suspension polymerization of styrene and 1,4-butanediol dimethacrylate. The copolymer was chloromethylated to 2.36 mmol Cl/g. The functionalized resin was found to possess all the physicochemical properties similar to Merrifield resin. The free peptide was obtained in high yield and purity as judged by RP-HPLC and characterized by amino acid analysis and ESI-MS.
Authors:
M K Kumar; B Mathe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of peptide science : an official publication of the European Peptide Society     Volume:  7     ISSN:  1075-2617     ISO Abbreviation:  J. Pept. Sci.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9506309     Medline TA:  J Pept Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  606-12     Citation Subset:  IM    
Affiliation:
School of Chemical Sciences, Mahatma Gandhi University, Kottayam, India.
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MeSH Terms
Descriptor/Qualifier:
Chromatography, High Pressure Liquid / methods
Galanin / chemical synthesis*,  chemistry
Humans
Peptide Fragments / chemical synthesis,  chemistry
Polystyrenes / chemistry*
Spectrometry, Mass, Electrospray Ionization / methods
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/Polystyrenes; 88813-36-9/Galanin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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