Document Detail


Gating information by two-state membrane potential fluctuations.
MedLine Citation:
PMID:  17314238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two-state voltage fluctuations between a hyperpolarized down-state and a depolarized up-state have been observed experimentally in a wide variety of neurons across brain regions. Using a biophysical model, we show that synaptic input by NMDA receptors can cause such membrane potential fluctuations. In this model, when a neuron is driven by two input pathways with different AMPA/NMDA receptor content, the NMDA-rich input causes up-state transitions, whereas the AMPA-rich input generates spikes only in the up-state. Therefore the NMDA-rich pathway can gate input from an AMPA pathway in an all-or-none fashion by switching between different membrane potential states. Furthermore, once in the up-state, the NMDA-rich pathway multiplicatively increases the gain of a neuron responding to AMPA-rich input. This proposed mechanism for two-state fluctuations directly suggests specific computations, such as gating and gain modulation based on the distinct receptor composition of different neuronal pathways. The dynamic gating of input by up- and down-states may be an elementary operation for the selective routing of signals in neural circuits, which may explain the ubiquity of two-state fluctuations across brain regions.
Authors:
A Kepecs; S Raghavachari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-21
Journal Detail:
Title:  Journal of neurophysiology     Volume:  97     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-05     Completed Date:  2007-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3015-23     Citation Subset:  IM    
Affiliation:
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. kepecs@cshl.edu
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Brain / cytology,  physiology*
Dendrites / physiology
Electrophysiology
Excitatory Postsynaptic Potentials / physiology
Ion Channel Gating / physiology
Membrane Potentials / physiology*
Models, Neurological
Nerve Net / cytology,  physiology
Neurons / physiology*
Poisson Distribution
Receptors, AMPA / physiology
Receptors, N-Methyl-D-Aspartate / physiology*
Chemical
Reg. No./Substance:
0/Receptors, AMPA; 0/Receptors, N-Methyl-D-Aspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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