| Gated blood-pool studies of cardiac function in the rat and marmoset. | |
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MedLine Citation:
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PMID: 6875683 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To develop a sensitive, relatively noninvasive method for monitoring cardiac function in small laboratory animals, equilibrium gated blood-pool imaging (with Tc-99m RBC) was adapted for use in an inbred strain of laboratory rats of 400-470 g body weight and in marmosets of 320-400 g body weight. A 2-mm pinhole collimator was fitted to the gamma camera to produce a distinct image of the left ventricle following intravenous injection of 5 mCi of pertechnetate. Reproducible and consistent data for heart rate, left-ventricular ejection fraction, and peak ejection rate were obtained from studies on 13 male rats and five marmosets maintained on constant diets. An intravenous injection of 0.4 microgram of isoprenaline led to predictable increases in heart rate, left-ventricular ejection fraction, and peak ejection rate, and provided evidence of the sensitivity of the method in monitoring heart function in small laboratory animals. |
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Authors:
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G H McIntosh; L R Barnden; I H Buttfield; J S Charnock |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 24 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-09-09 Completed Date: 1983-09-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 728-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Laboratory / physiology* Callithrix Heart / drug effects, physiology, radionuclide imaging* Heart Rate Heart Ventricles / radionuclide imaging Isoproterenol / pharmacology Male Myocardial Contraction Rats Rats, Inbred Strains Stroke Volume Technetium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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7440-26-8/Technetium; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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