Document Detail

Gated blood pool SPECT improves reproducibility of right and left ventricular Fourier phase analysis in radionuclide angiography.
MedLine Citation:
PMID:  14971618     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The ventricular phase angle, a parametric method applied to Fourier phase analysis (FPA) in radionuclide ventriculography, allows the quantitative analysis of ventricular contractile synchrony. However, FPA reproducibility using gated blood pool SPECT (GBPS) has not been fully evaluated. The present study evaluates whether by using GBPS, the reproducibility of FPA could be improved over that in planar radionuclide angiography (PRNA). METHODS: Forty-three subjects underwent both GBPS and PRNA, of which 10 subjects were normal controls, 25 had dilated cardiomyopathy, and 8 had various heart diseases. Interventricular contractile synchrony was measured as the absolute difference in RV and LV mean ventricular phase angle as delta(phi) (RV - LV). Intraventricular contractile synchrony was measured as the standard deviation of the mean phase angle for the RV and LV blood pools (RVSD(phi), LVSD(phi)). Two nuclear physicians processed the same phase images of GBPS to evaluate the interobserver reproducibility of the phase angles using data from the 43 study participants. Phase images acquired from PRNA were processed in the same manner. RESULTS: Excellent reproducibility of delta(phi) (RV - LV) was obtained with both GBPS (Y = -3.10 + 0.89 x X; r = 0.901) and PRNA (Y = -4.51 + 0.81 x X; r = 0.834). In regard to RVSD(phi) reproducibility was not adequate with PRNA (Y = 18.56 + 0.35 x X; r = 0.424), while it was acceptable with GBPS (Y = 5.22 + 0.85 x X; r = 0.864). LVSD(phi) reproducibility was superior using both GBPS (Y = 4.15 + 0.97 x X; r = 0.965) and PRNA (Y = -0.55 + 0.98 x X; r = 0.910). CONCLUSION: Our results demonstrate FPA obtained using GBPS to be highly reproducible for evaluating delta(phi) (RV - LV), RVSD(phi) and LVSD(phi), in comparison with the PRNA method. We thus consider GBPS appropriate for evaluating ventricular contractile synchrony.
Itaru Adachi; Hiroyuki Akagi; Tatsuya Umeda; Michihiro Suwa; Tsuyoshi Komori; Yasuharu Ogura; Keita Utsunomiya; Yasushi Kitaura; Isamu Narabayashi
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Validation Studies    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  17     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-02-19     Completed Date:  2004-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  711-6     Citation Subset:  IM    
Department of Radiology, Osaka Medical College, Takatsuki, Japan.
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MeSH Terms
Fourier Analysis
Gated Blood-Pool Imaging / methods*
Heart Diseases / radionuclide imaging*
Image Enhancement / methods*
Image Interpretation, Computer-Assisted / methods*
Middle Aged
Observer Variation
Radionuclide Angiography / methods
Reproducibility of Results
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon / methods*
Ventriculography, First-Pass / methods*

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