| Gated TI-201 myocardial perfusion SPECT: application of energy window optimization. | |
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MedLine Citation:
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PMID: 10401998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: TI-201 scintigraphy is plagued with poor image quality because of the low-energy photons of TI-201 decay. Traditionally, a narrow 20% window centered on 71-72 keV has been used to improve sensitivity. Recent studies indicate that better imaging may be possible by optimizing the energy window to 34% centered on 77 keV. In this study, energy window optimization (EWO) was applied to gated TI-201 myocardial perfusion SPECT, and myocardial functional parameters were compared for gated TI-201 SPECT and gated Tc-99m sestamibi (Tc-99m MIBI) SPECT. METHODS: Count statistics for standard and optimal TI-201 myocardial scintigraphy were noted in 25 patients by assessing the total counts in a mid-ventricular slice of a rest-gated TI-201 myocardial SPECT study. The feasibility of performing functional studies with the application of EWO to TI-201 was assessed using the count statistics of a mid-ventricular slice of an optimized gated TI-201 SPECT study and a gated Tc-99m MIBI SPECT study. The functional parameters (ejection fraction, wall motion, and thickening) of TI-201 with EWO and Tc-99m MIBI were compared in 60 patients who underwent rest-gated TI-201 SPECT followed by poststress gated Tc-99m MIBI SPECT. The left ventricular ejection fraction was calculated using commercially available software, whereas wall thickness and motion were assessed by the consensus of two readers. RESULTS: The application of EWO increased available counts by more than 25%. It also resulted in sufficient counts being available to perform gated TI-201 SPECT without increasing acquisition times or the dose of TI-201. The average ejection fraction was 60.4% for gated TI-201 SPECT and 59.6% for gated Tc-99m MIBI SPECT (not significantly different). Overall, the image quality was rated excellent in 12% for TI-201 and Tc-99m MIBI and good in 50% and 62%, respectively, and poor in 38% and 26%, respectively. CONCLUSION: The application of EWO to TI-201 SPECT allows myocardial functional parameters to be assessed without having to increase the acquisition times or the administered dose of TI-201. |
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Authors:
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S S Wadhwa; R Mansberg; D Wilkinson; D Abbati |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 24 ISSN: 0363-9762 ISO Abbreviation: Clin Nucl Med Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-08-11 Completed Date: 1999-08-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 479-82 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Wollongong Hospital, New South Wales, Australia. swadhwa@ozemail.com.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Gated Blood-Pool Imaging / methods* Heart / radionuclide imaging* Humans Image Enhancement Male Middle Aged Radiopharmaceuticals / diagnostic use Sensitivity and Specificity Stroke Volume* Technetium Tc 99m Sestamibi / diagnostic use Thallium Radioisotopes / diagnostic use Tomography, Emission-Computed, Single-Photon / instrumentation, methods* Ventricular Function, Left* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 0/Thallium Radioisotopes; 109581-73-9/Technetium Tc 99m Sestamibi |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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