Document Detail

Gated SPECT perfusion imaging for the simultaneous assessment of myocardial perfusion and ventricular function in the BARI 2D trial: an initial report from the Nuclear Core Laboratory.
MedLine Citation:
PMID:  16464721     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial, a National Heart, Lung, and Blood Institute-sponsored study in type 2 diabetic patients with coronary artery disease, completed patient recruitment in March 2005. This trial had a nuclear substudy in addition to many other substudies. METHODS AND RESULTS: After patient enrollment, adenosine gated single photon emission computed tomography perfusion imaging is performed at years 1 and 3. The images are interpreted at the core laboratory. Among the objectives of the nuclear substudy are (1) to determine the impact of the mode of therapy on left ventricular function, extent of ischemia, and scar; (2) to determine the impact of therapy on the progression/regression of ischemia/scar and changes in left ventricular function between years 1 and 3; and (3) to determine the independent and incremental prognostic value of ischemia, scar, and left ventricular function on the primary and secondary endpoints of the trial in the entire patient population and specified subgroups such as women, elderly patients, and minorities. CONCLUSIONS: This article describes the methodology and the initial experience of the nuclear core laboratory in this large multicenter trial and provides a summary of variables that are available for future analysis by the working group.
Ami E Iskandrian; Jack Heo; Deval Mehta; E Lindsey Tauxe; Michael Yester; Mary Beth Hall; Joan M MacGregor
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  13     ISSN:  1071-3581     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-02-08     Completed Date:  2006-06-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-90     Citation Subset:  IM    
BARI 2D Nuclear Cardiology Core Laboratory, University of Alabama at Birmingham, Birmingham, AL 35294-0006, USA.
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MeSH Terms
Adenosine / diagnostic use
Clinical Trials as Topic
Coronary Artery Bypass / statistics & numerical data
Coronary Artery Disease / epidemiology*,  radionuclide imaging*,  surgery
Diabetes Mellitus, Type 2 / epidemiology,  radionuclide imaging*,  surgery
Gated Blood-Pool Imaging / statistics & numerical data*
Reproducibility of Results
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon / methods*,  statistics & numerical data
Treatment Outcome
United States / epidemiology
Ventricular Dysfunction, Left / epidemiology*,  radionuclide imaging*,  surgery
Reg. No./Substance:

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