Document Detail

Gastrotonometry represents dramatic increase in PcO2 after acetazolamide administration.
MedLine Citation:
PMID:  10849018     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We sought to evaluate the parameters of CO2 transport during the administration of acetazolamide in order to assess the role of carbonic anhydrase in CO2 transport. MATERIALS AND METHODS: The partial pressure of carbon dioxide in tissue (PtCO2), arterial blood (PaCO2) and end-tidal gas (PETCO2) were monitored to study the correlation between PaCO2, PtCO2 and PETCO2 in spontaneously breathing healthy volunteers after the intravenous administration of acetazolamide 6 mg kg-1. RESULTS: At 60 min after the administration of acetazolamide, the PtCO2 peaked at more than 60 mmHg, and although it decreased by 90 min, it then remained stable above the baseline value. The PaCO2 did not change and the PETCO2 decreased significantly. The changes in PtCO2 were greater than those of either PaCO2 or PETCO2. The minute ventilation increased progressively throughout the study. CONCLUSIONS: We concluded that gastrotonometry represents a new method for monitoring the dramatic increase in PtCO2 induced by drugs such as acetazolamide clinically, and that it could be a warning against acetazolamide administration in severe patients without keeping a ventilation and circulation reserve.
K Taki; K Oogushi; K Tozuka
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  30     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-04     Completed Date:  2000-08-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  501-4     Citation Subset:  IM    
Department of Emergency Medicine, Saga Medical College, Saga, Japan.
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MeSH Terms
Acetazolamide / administration & dosage*
Blood Pressure
Carbon Dioxide / metabolism*
Carbonic Anhydrase Inhibitors / administration & dosage*
Carbonic Anhydrases / metabolism
Gastric Mucosa / drug effects,  enzymology*
Heart Rate
Injections, Intravenous
Oxygen / metabolism
Partial Pressure
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 124-38-9/Carbon Dioxide; 59-66-5/Acetazolamide; 7782-44-7/Oxygen; EC Anhydrases
Comment In:
Eur J Clin Invest. 2000 Jun;30(6):467-8   [PMID:  10849011 ]

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