Document Detail

Gastroschisis and pseudoephedrine during pregnancy.
MedLine Citation:
PMID:  15532139     Owner:  HSR     Status:  MEDLINE    
(1) Gastroschisis is a severe defect in the closure of the abdominal wall in newborns. The incidence seems to be increasing. (2) Three case-control studies have examined pseudoephedrine exposure among mothers of children born with gastroschisis. The evidence is weak but consistent. In two studies, pseudoephedrine exposure was associated with a significant odds ratio. In the most recent study, the risk of gastroschisis was increased 4.2-fold among women taking the pseudoephedrine-paracetamol combination (95% confidence interval 1.9-9.2). Paracetamol is not known to cause this malformation. (3) Pseudoephedrine is a sympathomimetic vasoconstrictor contained in many over-the-counter oral decongestants sold in France. (4) In practice, it is best to avoid prescribing, dispensing or using preparations containing pseudoephedrine during pregnancy.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prescrire international     Volume:  13     ISSN:  1167-7422     ISO Abbreviation:  Prescrire Int     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-11-08     Completed Date:  2004-11-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9439295     Medline TA:  Prescrire Int     Country:  France    
Other Details:
Languages:  eng     Pagination:  141-3     Citation Subset:  T    
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MeSH Terms
Abnormalities, Drug-Induced / etiology
Acetaminophen / adverse effects
Adrenergic Agents / adverse effects*
Case-Control Studies
Ephedrine / adverse effects*
Gastroschisis / chemically induced*,  epidemiology
Infant, Newborn
Maternal-Fetal Exchange
Nonprescription Drugs / adverse effects*
Odds Ratio
Pregnancy Complications / drug therapy
Pregnancy Trimester, First
Prenatal Exposure Delayed Effects
Vasoconstrictor Agents / adverse effects
Reg. No./Substance:
0/Adrenergic Agents; 0/Nonprescription Drugs; 0/Teratogens; 0/Vasoconstrictor Agents; 103-90-2/Acetaminophen; 299-42-3/Ephedrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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