| Gastroprotective constituents of Salvia officinalis L. | |
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MedLine Citation:
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PMID: 19481590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in vitro experiments, the H(+),K(+)-ATPase activity was inhibited. Carnosol was identified as a possible active constituent for the gastroprotective effect of HE. |
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Authors:
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Bárbara Mayer; Cristiane Hatsuko Baggio; Cristina Setim Freitas; Ana Cristina dos Santos; André Twardowschy; Heros Horst; Moacir Geraldo Pizzolatti; Gustavo Amadeu Micke; Melina Heller; Elide Pereira dos Santos; Michel Fleith Otuki; Maria Consuelo Andrade Marques |
Publication Detail:
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Type: Journal Article Date: 2009-05-28 |
Journal Detail:
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Title: Fitoterapia Volume: 80 ISSN: 1873-6971 ISO Abbreviation: Fitoterapia Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2009-12-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: Netherlands |
Other Details:
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Languages: eng Pagination: 421-6 Citation Subset: IM |
Affiliation:
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Departamento de Farmacologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, PR, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid Animals Anti-Ulcer Agents / isolation & purification, pharmacology, therapeutic use* Diterpenes, Abietane / isolation & purification, pharmacology, therapeutic use* Ethanol Female Gastric Mucosa / drug effects* H(+)-K(+)-Exchanging ATPase / antagonists & inhibitors Phytotherapy* Plant Extracts / chemistry, pharmacology, therapeutic use* Plant Leaves Rats Rats, Wistar Salvia officinalis / chemistry* Stomach Ulcer / chemically induced, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Diterpenes, Abietane; 0/Plant Extracts; 5957-80-2/carnosol; 64-17-5/Ethanol; 64-19-7/Acetic Acid; EC 3.6.1.10/H(+)-K(+)-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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