Document Detail

Gastroprotective constituents of Salvia officinalis L.
MedLine Citation:
PMID:  19481590     Owner:  NLM     Status:  MEDLINE    
The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in vitro experiments, the H(+),K(+)-ATPase activity was inhibited. Carnosol was identified as a possible active constituent for the gastroprotective effect of HE.
Bárbara Mayer; Cristiane Hatsuko Baggio; Cristina Setim Freitas; Ana Cristina dos Santos; André Twardowschy; Heros Horst; Moacir Geraldo Pizzolatti; Gustavo Amadeu Micke; Melina Heller; Elide Pereira dos Santos; Michel Fleith Otuki; Maria Consuelo Andrade Marques
Publication Detail:
Type:  Journal Article     Date:  2009-05-28
Journal Detail:
Title:  Fitoterapia     Volume:  80     ISSN:  1873-6971     ISO Abbreviation:  Fitoterapia     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-08-31     Completed Date:  2009-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  16930290R     Medline TA:  Fitoterapia     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  421-6     Citation Subset:  IM    
Departamento de Farmacologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
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MeSH Terms
Acetic Acid
Anti-Ulcer Agents / isolation & purification,  pharmacology,  therapeutic use*
Diterpenes, Abietane / isolation & purification,  pharmacology,  therapeutic use*
Gastric Mucosa / drug effects*
H(+)-K(+)-Exchanging ATPase / antagonists & inhibitors
Plant Extracts / chemistry,  pharmacology,  therapeutic use*
Plant Leaves
Rats, Wistar
Salvia officinalis / chemistry*
Stomach Ulcer / chemically induced,  drug therapy*
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Diterpenes, Abietane; 0/Plant Extracts; 5957-80-2/carnosol; 64-17-5/Ethanol; 64-19-7/Acetic Acid; EC ATPase

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