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Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers.
MedLine Citation:
PMID:  21517098     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) seeds have long been used to treat warts, chapped skin, rheumatism, and neuralgia in traditional Chinese medicine (TCM). Recently, studies demonstrated its anti-inflammatory, antiproliferative, antitumor, and antiallergic activities. In the present study, we first report the gastroprotective effects of dehulled adlay (DA) seeds, which consist of bran (AB) and the endosperm (AE). The DA ethanolic extract (DAE) was prepared, along with the AB and the AE ethanolic extracts (ABE and AEE), and the inhibitory effects of these extracts were tested on the AGS gastric cancer cell line. Results indicated that the ABE showed better antiproliferative activity, and 19 compounds were purified from AB in a further phenolic compound-guided separation. Among the isolated compounds, caffeic acid and chlorogenic acid significantly suppressed the growth of AGS cells. In addition, the anti-ulcer activity of DA was examined in an indomethacin-induced gastric lesion model. The ulcer index (UI) and oxidative biomarkers in animals decreased, while the non-protein sulfhydryl (NPSH) groups were elevated when given DA. This is the first investigation of adlay's anti-ulcer activity, and we demonstrated that the antioxidative-active phenolic acids in DA contribute to some portion of the gastroprotective effects.
Authors:
Cheng-Pei Chung; Shih-Min Hsia; Ming-Yi Lee; Hong-Jhang Chen; Faiwen Cheng; Lu-Chi Chan; Yueh-Hsiung Kuo; Yun-Lian Lin; Wenchang Chiang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-25
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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