| Gastroprotective Effect of Rubia cordifolia Linn. on Aspirin Plus Pylorus-Ligated Ulcer. | |
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MedLine Citation:
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PMID: 21423635 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The present study was designed to investigate the effect of Rubia cordifolia (Rubiaceae) against experimentally induced gastric ulcer and compare activity with its fractions by employing aspirin plus pylorus-ligated ulcer screening model in Wistar rats. Total acidity, volume of gastric acid secretion, total acid output, and pepsin activity show significant reduction, when compared with the control group. The present study confirmed that chloroform fraction showed the significant activity at lower doses compared to parent extract. The mechanism can be attributed to decrease in gastric acid secretary activity along with strengthening of mucosal defensive mechanism by prostaglandin synthesis and antioxidant potential. |
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Authors:
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R S Deoda; Dinesh Kumar; S S Bhujbal |
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Publication Detail:
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Type: Journal Article Date: 2011-02-24 |
Journal Detail:
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Title: Evidence-based complementary and alternative medicine : eCAM Volume: 2011 ISSN: 1741-4288 ISO Abbreviation: Evid Based Complement Alternat Med Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-22 Completed Date: 2011-07-14 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 101215021 Medline TA: Evid Based Complement Alternat Med Country: England |
Other Details:
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Languages: eng Pagination: 541624 Citation Subset: - |
Affiliation:
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Marathwada Mitra Mandal's College of Pharmacy, Thergaon, Kalewadi, Pune 17, India. |
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