Document Detail


Gastrointestinal targets to modulate satiety and food intake.
MedLine Citation:
PMID:  20880099     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This review discusses the role of enteroendocrine cells in the gastrointestinal tract as chemoreceptors that sense intraluminal contents and induce changes in food intake through the release of signalling substances, such as satiety hormones. Recent evidence supports the concept that chemosensing in the gut involves G protein-coupled receptors (GPCRs) that are known to mediate gustatory signals in the oral cavity. GPCRs can be grouped into several families, depending on the stimuli to which they respond, e.g. proteins, amino acids, carbohydrates, fatty acids, or tastants. Sensing of these stimuli by GPCRs results in hormone secretions of enteroendocrine cells, which participate in the control of food intake. A better understanding of the stimuli that induce the strongest binding with these receptors, and thus induce a strong release of hormones, can be a very useful strategy for the development of novel foods in the treatment of obesity.
Authors:
M C P Geraedts; F J Troost; W H M Saris
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Publication Detail:
Type:  Journal Article     Date:  2010-09-06
Journal Detail:
Title:  Obesity reviews : an official journal of the International Association for the Study of Obesity     Volume:  12     ISSN:  1467-789X     ISO Abbreviation:  Obes Rev     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897395     Medline TA:  Obes Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  470-7     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. obesity reviews © 2010 International Association for the Study of Obesity.
Affiliation:
Departments of Human Biology Internal Medicine, Division of Gastroenterology and Hepatology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University Medical Centre +, Maastricht, The Netherlands.
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