Document Detail


Gastrointestinal symptoms and psychological well-being in patients with microscopic colitis.
MedLine Citation:
PMID:  23148737     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective. Microscopic colitis (MC) and irritable bowel syndrome (IBS) are both gastrointestinal disorders with female predominance that affect well-being. Autoantibodies against gonadotropin-releasing hormone (GnRH) have recently been detected in IBS patients. The purpose of this study was to compare gastrointestinal symptoms and well-being in MC female outpatients, with or without coexisting IBS-like symptoms, and to examine the prevalence of GnRH antibodies in these patients. Material and methods. Women with biopsy-verified MC, at any outpatient clinic of the Departments of Gastroenterology, Skåne, between 2002 and 2010 were invited to participate in the study. The questionnaires Gastrointestinal Symptom Rating Scale (GSRS), Psychological General Well-being Index (PGWB), Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS), and Rome III were answered and blood samples collected. Autoantibodies (IgG, IgA, and IgM) against GnRH and GnRH-R (extracellular peptide of receptor) were determined by an enzyme-linked immunosorbent assay. Results. Altogether, 158 (66%) of 240 invited patients with MC were recruited to the study. Of these, 133 (55%) patients also accepted to provide blood samples. Patients with IBS-like symptoms (55%) experienced more symptoms and worse psychological well-being in all dimensions in GSRS and PGWB, and in all symptoms but constipation in VAS-IBS compared to patients without IBS symptoms. Only a minority of patients expressed antibodies against GnRH or GnRH-R, which did not differ between groups. Conclusions. MC patients fulfilling criteria for IBS experience more gastrointestinal symptoms and worse psychological well-being than those who do not. Autoantibodies against GnRH or GnRH-R are not frequently observed in MC patients.
Authors:
Bodil Roth; Bodil Ohlsson
Related Documents :
24117647 - Upper esophageal sphincter dysfunction: diverticula-globus pharyngeus.
24382707 - Elevated serum monoclonal and polyclonal free light chains and interferon inducible pro...
23053897 - Small intestinal bacterial overgrowth in gastroparesis.
23700877 - The risk of thrombotic events in patients with liver cirrhosis.
16966507 - Distribution and outcome of symptomatic stenoses and occlusions in patients with acute ...
20635787 - Effect of fluticasone on neuropeptides in nasal lavage in persistent allergic rhinitis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  -     ISSN:  1502-7708     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Clinical Sciences, Division of Gastroenterology, Skåne University Hospital , Malmö, Lund University , Lund, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pn...
Next Document:  A 63-year-old woman presenting with a synovial sarcoma of the hand: a case report.