| Gastrointestinal symptoms in type-1 diabetes: Is it all about brain plasticity? | |
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MedLine Citation:
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PMID: 20813568 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Autonomic neuropathy seems to play a central role in the development of gastrointestinal symptoms in diabetes. In order to explore the neuronal mechanisms behind the symptoms we evaluated the brain processing of painful visceral stimuli. METHODS: Evoked brain potentials were recorded to assess the response to painful oesophageal electrical stimuli in 15 healthy volunteers and 14 type-1 diabetes patients with autonomic neuropathy and related gastrointestinal symptoms. Source reconstruction analysis (fixed Multiple Signal Classification (MUSIC) algorithm) was applied to estimate the location of the evoked electrical activity in the brain. RESULTS: The patients had increased oesophageal sensory thresholds compared to the controls (P=0.004). The latencies of the evoked brain potentials at vertex (Cz) were increased (P=0.007) and amplitudes reduced (P=0.011) in diabetics. Compared with controls the patients had a posterior shift of the electrical sources in the anterior cingulate cortex at 54ms, and additional sources close to the posterior insula at 95ms and in medial frontal gyrus at 184ms. CONCLUSIONS: There is evidence of altered central processing to visceral stimulation, and both peripheral and central mechanisms seem involved. Central neuronal reorganisation may contribute to our understanding of the gastrointestinal symptoms in patients with diabetic autonomic neuropathy and this may guide development and evaluation of new treatment modalities. |
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Authors:
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Jens Brøndum Frøkjær; Line Lindhardt Egsgaard; Carina Graversen; Eirik Søfteland; Georg Dimcevski; Rolf Ankerlund Blauenfeldt; Asbjørn Mohr Drewes |
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Publication Detail:
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Type: Journal Article Date: 2010-09-01 |
Journal Detail:
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Title: European journal of pain (London, England) Volume: 15 ISSN: 1532-2149 ISO Abbreviation: Eur J Pain Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9801774 Medline TA: Eur J Pain Country: England |
Other Details:
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Languages: eng Pagination: 249-57 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Mech-Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark; Department of Radiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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