Document Detail

Gastrointestinal stromal tumors--frequency, malignancy, and new prognostic factors: the experience of a single institution.
MedLine Citation:
PMID:  18304753     Owner:  NLM     Status:  MEDLINE    
Gastrointestinal stromal tumors (GISTs) are c-Kit-positive neoplasms of the digestive tract. Few studies have reported their real incidence and malignancy. Two systems of risk assessment of aggressive behavior were recently proposed. The aims of our study were (1) to ascertain the frequency of GISTs and their clinical behavior in a large series of cases with a long-term follow-up, (2) to evaluate the prognostic value of two well-known risk assessment classifications, and (3) to propose an alternative prognostic index based on our data. Statistical analyses were performed to identify possible predictors of malignant behavior. One hundred and eighteen out of 169 (70%) mesenchymal tumors were GISTs. They were located in the stomach (57%), small intestine (31%), colon/rectum (6%), and omentum/mesentery (6%). Eighteen cases (16%) showed malignant behavior, with local recurrence in eight cases and distant metastases in 11 cases. Fifteen of 114 (13%) patients died of disease within 74 months, whereas 63 (55%) patients were still alive after a median period of 78 months. At multivariate analysis, high-risk category (according to Fletcher's criteria), omental/colorectal site, and younger patient age were independent predictors of malignant behavior. In addition to the evaluation of risk category, tumor site and patient age helped to better identify patients requiring stricter monitoring.
Valentina Bertolini; Anna Maria Chiaravalli; Catherine Klersy; Claudia Placidi; Silvia Marchet; Luigi Boni; Carlo Capella
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Publication Detail:
Type:  Journal Article     Date:  2008-03-04
Journal Detail:
Title:  Pathology, research and practice     Volume:  204     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  219-33     Citation Subset:  IM    
Department of Human Morphology, Section of Anatomic Pathology, University of, Insubria and Ospedale di Circolo, Varese, Italy.
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MeSH Terms
Age Factors
Disease-Free Survival
Gastrointestinal Stromal Tumors / classification,  epidemiology*,  mortality,  pathology*,  therapy
Health Status Indicators
Kaplan-Meiers Estimate
Middle Aged
Models, Biological
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Recurrence, Local*
Neoplasm Staging
Proportional Hazards Models
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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