| Gastrointestinal regulatory peptides and their effects on fat tissue. | |
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MedLine Citation:
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PMID: 19855273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Regulation of body weight, food intake and appetite is complex and the gastrointestinal tract represents a central organ participating in the regulation of energy homeostasis by signaling to other tissues relevant in this context. This update will provide information regarding recent advances in the understanding of the interaction of gastrointestinal peptides with adipocytes in fat tissue and which biological effects they may exert. RECENT FINDINGS: Several gastrointestinal peptides signal to their functional cognate receptors on adipocytes in white adipose tissue (WAT) thereby regulating glucose homeostasis, lipogenesis, lipolysis, free fatty acid release and may also participate in adipocyte differentiation. SUMMARY: Gastrointestinal peptides emanate from enteroendocrine cells in the luminal digestive tract and are critical regulators of energy homeostasis, food intake and appetite. Recent studies have identified that gastrointestinal peptides communicate with WAT and exert their biological effects on fat cells. Fundamental understanding of gastrointestinal peptides and their interaction with adipocytes will provide future insights for the development of pharmacological targets in the treatment of obesity and insulin resistant states. |
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Authors:
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Ishita D Majumdar; Horst C Weber |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current opinion in endocrinology, diabetes, and obesity Volume: 17 ISSN: 1752-2978 ISO Abbreviation: Curr Opin Endocrinol Diabetes Obes Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2009-12-22 Completed Date: 2010-03-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101308636 Medline TA: Curr Opin Endocrinol Diabetes Obes Country: England |
Other Details:
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Languages: eng Pagination: 51-6 Citation Subset: IM |
Affiliation:
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Section of Gastroenterology, Boston University School of Medicine, Boston, Massachusetts 02118-2518, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes, White
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physiology Adipose Tissue, White / physiology* Animals Appetite / physiology Appetite Regulation / physiology Energy Metabolism Gastric Inhibitory Polypeptide / physiology Gastrointestinal Hormones / physiology* Ghrelin / physiology Glucagon-Like Peptide 1 / physiology Homeostasis Humans Neuropeptide Y / physiology Peptide YY / physiology Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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DK46200/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Hormones; 0/Ghrelin; 0/Neuropeptide Y; 106388-42-5/Peptide YY; 59392-49-3/Gastric Inhibitory Polypeptide; 89750-14-1/Glucagon-Like Peptide 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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