Document Detail

Gastrointestinal regulation of food intake: do gut motility, enteric nerves and entero-hormones play together?
MedLine Citation:
PMID:  22322652     Owner:  NLM     Status:  MEDLINE    
The gastrointestinal system can be considered the gateway for food entry in our body. Rather than being a passive player, it is now clear that gut strongly influence the feeding behavior and contribute to maintain energy balance with different signals. The aim of this review is to summarize the current knowledge about the role of gastrointestinal tract in the control of food intake, by focusing on the interplay existing between the enteric nervous system and gastrointestinal hormones and their ability to modulate digestive motility and sensitivity. Also the latest advances about the contribution of gut microbiota and gastrointestinal taste receptors are described. From the reported data it clearly emerges that gut hormones together with nervous signals likely contribute to the regulation of energy balance and modulate food intake through the control of digestive motility and sensations. The close linkage among gastrointestinal hormones, the gut and the central nervous systems appears very intriguing and has induced the development of a new field of research: the gastroendocrinology.
R Cuomo; A D'Alessandro; P Andreozzi; L Vozzella; G Sarnelli
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Minerva endocrinologica     Volume:  36     ISSN:  0391-1977     ISO Abbreviation:  Minerva Endocrinol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-02-10     Completed Date:  2012-05-22     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  8406505     Medline TA:  Minerva Endocrinol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  281-93     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, University of Naples Federico II, Naples, Italy.
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MeSH Terms
Appetite / physiology
Dietary Carbohydrates / pharmacology
Dietary Fats / pharmacology
Eating / physiology*
Enteric Nervous System / physiology*
Gastrointestinal Hormones / physiology*
Gastrointestinal Motility / drug effects,  physiology*
Ghrelin / physiology
Hunger / physiology
Hypothalamus / physiology
Mechanoreceptors / physiology
Metagenome / physiology
Models, Biological
Motilin / physiology
Neurotransmitter Agents / physiology
Receptors, G-Protein-Coupled / physiology
Satiation / physiology
Stomach / physiology
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Gastrointestinal Hormones; 0/Ghrelin; 0/Neurotransmitter Agents; 0/Receptors, G-Protein-Coupled; 52906-92-0/Motilin

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