| Gastrointestinal permeability and absorptive capacity in sepsis. | |
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MedLine Citation:
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PMID: 8674326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess gastrointestinal permeability and functional absorptive capacity in patients with sepsis. DESIGN: Case control study to analyze gastrointestinal permeability and functional absorptive capacity of septic patients by differential saccharide absorption (from an oral test solution) and excretion. SETTING: The intensive Therapy Unit of St. Thomas' Hospital, London, UK. PATIENTS: Twenty patients with a mean Acute Physiology and Chronic Health Evaluation (APACHE) II score of 18.4 who were admitted to the intensive care unit with a diagnosis of sepsis. All patients were on enteral feeding. Patients with abdominal pathology were excluded. INTERVENTIONS: An oral test solution containing 5 g of lactulose, 1 g of L-rhamnose, 0.5 g of D-xylose, and 0.2 g of 3-O-methyl-D-glucose dissolved in water to a final volume of 100 mL was administered to patients and controls. Urine was collected for 5 hrs starting immediately after administration of the test solution and the saccharide content of the urine was estimated and expressed as a percentage recovery of the oral test solution. MEASUREMENTS AND MAIN RESULTS: Septic patients had increased lactulose/L-rhamnose urine excretion ratios (0.23 +/- 0.19) compared with control subjects (0.03 +/- 0.01, p < .001), consistent with increased gastrointestinal permeability in sepsis. Septic patients had decreased L-rhamnose/3-O-methyl-D-glucose urine excretion ratios (0.14 +/- 0.07) compared with normal controls (0.28 +/- 0.08, p < .001), consistent with decreased gastrointestinal functional absorptive capacity in sepsis. CONCLUSIONS: Patients with acute sepsis exhibit increased gastrointestinal permeability and decreased gastrointestinal functional absorptive capacity in comparison with healthy control subjects. These abnormalities may contribute to the pathophysiology of sepsis. |
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Authors:
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J D Johnston; C J Harvey; I S Menzies; D F Treacher |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Critical care medicine Volume: 24 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-08-09 Completed Date: 1996-08-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1144-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Chemical Pathology, United Medical School, St. Thomas' Hospital, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-O-Methylglucose Absorption Acute Disease Adult Aged Digestive System / physiopathology* Female Humans Intestinal Absorption / physiology* Lactulose / metabolism Male Methylglucosides / metabolism Middle Aged Permeability Rhamnose / metabolism Sepsis / physiopathology* Xylose / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Methylglucosides; 0/Xylose; 10485-94-6/Rhamnose; 146-72-5/3-O-Methylglucose; 4618-18-2/Lactulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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