Document Detail

Gastrointestinal peptides and regulation of gastric acid secretion.
MedLine Citation:
PMID:  19855274     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Update on the role of gastrointestinal peptides in regulating gastric acid secretion. RECENT FINDINGS: A novel transgenic mouse that expresses the entire human gastrin gene locus in G-cells of gastrin-null mice will facilitate investigation of gastrin gene regulatory elements. Isolation of a highly homogeneous population of G-cells permits the elucidation of stimulatory and inhibitory ligands without the confounding presence of other neuroendocrine cells. The use of somatostatin receptor knockout mice demonstrated the plasticity of gastric acid regulatory mechanisms and compensation by upregulation of the galanin pathway which inhibits secretion by enterochromaffin-like cells. The importance of adenosine in regulating somatostatin release was shown using adenosine receptor knockout mice. SUMMARY: The importance of gastrointestinal peptides for regulating gastric acid is evident. Ongoing investigations will characterize the mechanisms underlying actions of these agents on gastric acid secretion, particularly with regard to their combinatorial effects and interplay with other acid-regulating pathways.
Erik C von Rosenvinge; Jean-Pierre Raufman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in endocrinology, diabetes, and obesity     Volume:  17     ISSN:  1752-2978     ISO Abbreviation:  Curr Opin Endocrinol Diabetes Obes     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2009-12-22     Completed Date:  2010-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308636     Medline TA:  Curr Opin Endocrinol Diabetes Obes     Country:  England    
Other Details:
Languages:  eng     Pagination:  40-3     Citation Subset:  IM    
Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore VA Medical Center, Baltimore, Maryland 21201, USA.
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MeSH Terms
Gastric Acid / secretion*
Gastrin-Secreting Cells / physiology,  secretion
Gastrins / deficiency,  genetics,  physiology
Gastrointestinal Hormones / physiology*
Ghrelin / physiology
Intracellular Signaling Peptides and Proteins / physiology
Mice, Knockout
Mice, Transgenic
Natriuretic Peptides / physiology
Neuropeptides / physiology
Peptides / physiology
Receptors, Somatostatin / deficiency,  genetics
Somatostatin / physiology
Reg. No./Substance:
0/Gastrins; 0/Gastrointestinal Hormones; 0/Ghrelin; 0/Intracellular Signaling Peptides and Proteins; 0/Natriuretic Peptides; 0/Neuropeptides; 0/Peptides; 0/Receptors, Somatostatin; 0/Sstr2 protein, mouse; 0/orexins; 51110-01-1/Somatostatin; 9007-67-4/enterogastrone

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