Document Detail

Gastrointestinal neuromuscular pathology in chronic constipation.
MedLine Citation:
PMID:  21382578     Owner:  NLM     Status:  MEDLINE    
Some patients with chronic constipation may undergo colectomy yielding tissue appropriate to diagnosis of underlying neuromuscular pathology. The analysis of such tissue has, over the past 40 years, fueled research that has explored the presence of neuropathy, myopathy and more recently changes in interstitial cells of Cajal (ICC). In this chapter, the data from these studies have been critically reviewed in the context of the significant methodological and interpretative issues that beset the field of gastrointestinal neuromuscular pathology. On this basis, reductions in ICC appear to a consistent finding but one whose role as a primary cause of slow-transit constipation requires further evaluation. Findings indicative of significant neuropathy or myopathy are variable and in many studies subject to considerable methodological bias. Methods with practical diagnostic utility in the individual patient have rarely been employed and require further validation in respect of normative data.
Charles H Knowles; Gianrico Farrugia
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Best practice & research. Clinical gastroenterology     Volume:  25     ISSN:  1532-1916     ISO Abbreviation:  Best Pract Res Clin Gastroenterol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-08     Completed Date:  2011-06-24     Revised Date:  2014-07-16    
Medline Journal Info:
Nlm Unique ID:  101120605     Medline TA:  Best Pract Res Clin Gastroenterol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  43-57     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Chronic Disease
Colon / innervation*,  surgery
Constipation / pathology,  physiopathology*,  surgery
Enteric Nervous System / physiopathology*
Gastrointestinal Transit*
Interstitial Cells of Cajal / pathology
Muscle, Smooth / innervation*,  surgery
Research Design
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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