Document Detail

Gastrointestinal metastases from malignant melanoma.
MedLine Citation:
PMID:  7551258     Owner:  NLM     Status:  MEDLINE    
Between 1980 and 1992, 68 patients with clinical indications of involvement of the gastrointestinal (GI) tract with metastatic melanoma were treated at Roswell Park Cancer Institute. Presenting symptoms were anaemia, abdominal pain, nausea and vomiting. Sites commonly involved were the small bowel (75%), the large intestine (25%), and the stomach (16%). Twenty-one patients were considered unsuitable for surgery; their median survival after diagnosis of GI metastases was 2.9 months. Forty-seven patients underwent abdominal surgery; effective palliation was achieved in most of them. Complete resection of GI metastases was accomplished in 47% of patients. The median survival after operation was 27.6 months for patients with complete resection of GI metastasis and no other disease, 5.1 months for patients with resection of involved GI tract and other metastases present, and 1.9 months for patients who had a by-pass procedure only. The 5-year survival for patients with complete resection of GI metastases and no other evidence of disease was 28.3%. The other groups had only 1-year survivors. Surgical intervention is justified on the basis of these findings, and extended palliation can be achieved in patients with complete resection of metastatic disease.
N Ricaniadis; M M Konstadoulakis; D Walsh; C P Karakousis
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Surgical oncology     Volume:  4     ISSN:  0960-7404     ISO Abbreviation:  Surg Oncol     Publication Date:  1995  
Date Detail:
Created Date:  1995-11-09     Completed Date:  1995-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9208188     Medline TA:  Surg Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  IM    
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
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MeSH Terms
Disease-Free Survival
Follow-Up Studies
Gastrointestinal Neoplasms / mortality,  secondary*,  surgery
Melanoma / mortality,  pathology*,  surgery
Middle Aged
Skin Neoplasms / mortality,  pathology*,  surgery
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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