Document Detail

Gastrointestinal malformations in two infants born to women with hyperthyroidism untreated in the first trimester.
MedLine Citation:
PMID:  12660909     Owner:  NLM     Status:  MEDLINE    
We report two infants with gastrointestinal anomalies: one with esophageal atresia and tracheo-esophageal fistula and the other with biliary tree atresia, born to hyperthyroid women diagnosed and treated with methimazole after 14 weeks' gestation. Euthyroidism was documented in both infants. These cases raise the issue of whether untreated hyperthyroidism and not methimazole intake is the teratogen.
Muhieddine Seoud; Anwar Nassar; Ihab Usta; Mohammad Mansour; Ibrahim Salti; Khaled Younes
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  20     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-27     Completed Date:  2003-07-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM    
Obstetrics and Gynecology, The American University of Beirut Medical Center, New York, New York 10022, USA.
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MeSH Terms
Abnormalities, Multiple / chemically induced,  etiology*
Antithyroid Agents / administration & dosage,  adverse effects
Biliary Atresia / chemically induced,  etiology*,  surgery
Digestive System / drug effects
Digestive System Abnormalities*
Esophageal Atresia / chemically induced,  etiology*,  surgery
Hyperthyroidism / complications*,  drug therapy
Infant, Newborn
Methimazole / administration & dosage,  adverse effects
Pregnancy Complications / drug therapy*
Time Factors
Tracheoesophageal Fistula / chemically induced,  etiology*,  surgery
Treatment Outcome
Reg. No./Substance:
0/Antithyroid Agents; 60-56-0/Methimazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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