|Gastrointestinal involvement revealing Henoch Schonlein purpura in adults: Report of three cases and review of the literature.|
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|PMID: 21958439 Owner: NLM Status: PubMed-not-MEDLINE|
|The diagnosis of Henoch-Schonlein purpura (HSP) is difficult, especially when abdominal symptoms precede cutaneous lesions. We report three cases of adult HSP revealed by gastrointestinal (GI) involvement.|
|Amira Hamzaoui; Wissem Melki; Olfa Harzallah; Leila Njim; Rim Klii; Silvia Mahjoub|
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|Type: Journal Article Date: 2011-09-29|
|Title: International archives of medicine Volume: 4 ISSN: 1755-7682 ISO Abbreviation: Int Arch Med Publication Date: 2011|
|Created Date: 2012-08-23 Completed Date: 2012-10-02 Revised Date: 2012-11-09|
Medline Journal Info:
|Nlm Unique ID: 101317943 Medline TA: Int Arch Med Country: England|
|Languages: eng Pagination: 31 Citation Subset: -|
|APA/MLA Format Download EndNote Download BibTex|
Journal ID (nlm-ta): Int Arch Med
Publisher: BioMed Central
Copyright ©2011 Hamzaoui et al; licensee BioMed Central Ltd.
Received Day: 23 Month: 1 Year: 2011
Accepted Day: 29 Month: 9 Year: 2011
collection publication date: Year: 2011
Electronic publication date: Day: 29 Month: 9 Year: 2011
Volume: 4First Page: 31 Last Page: 31
Publisher Id: 1755-7682-4-31
PubMed Id: 21958439
|Gastrointestinal involvement revealing Henoch Schonlein purpura in adults: Report of three cases and review of the literature|
|Amira Hamzaoui||Email: email@example.com|
|Wissem Melki2||Email: firstname.lastname@example.org|
|Olfa Harzallah||Email: email@example.com|
|Leila Njim3||Email: firstname.lastname@example.org|
|Rim Klii1||Email: email@example.com|
|Silvia Mahjoub1||Email: firstname.lastname@example.org|
1Department of Internal Medicine, Fattouma Bourguiba Hospital, Monastir, Tunisia
2Department of Hepatogastroenterology, Fattouma Bourguiba Hospital, Monastir, Tunisia
3Departement of Anatomopathology, Fattouma Bourguiba Hospital, Monastir, Tunisia
Henoch Schonlein purpura (HSP) is a leucocytoclastic vasculitis involving small vessel with deposition of immune Ig A complexes. HSP primarily affects children, (approximately 15 cases/100.000 per year) . It is less common among adults. Clinically, HSP is characterized by palpable purpura, arthritis, renal and gastrointestinal involvement. Among adults, the incidence of HSP, the clinical features and the severity seems to be different compared to children . Except for potential intestinal complications, its prognosis is usually excellent. However, nephritis is another complication that might have less prognosis. We report three cases of adult-onset HSP revealed by gastrointestinal (GI) involvements.
Over a period of 2 years (2009-2010), three patients with adult-onset HSP were admitted to Department of Internal Medicine. The clinical profiles, along with laboratory and radiological data, of the three patients are shown in Table 1. GI involvements were the first symptoms in the 3 cases. The delay between the GI involvement and the others symptoms is shown in table 1. Skin biopsy showed leucocytoclastic vasculitis with Ig A and C3 deposits in direct immunofluorescence (DIF) in the 3 cases.
The oesogastroduodenal endoscopy with biopsy showed the presence of helicobacter pylori in case 1 and 2. The rapid urease tests for Helicobacter pylori was not done.
In the first case, the colonoscopy showed the presence of colic poliposis with moderate dysplasia on the biopsy. Tumor markers (ACE, AFP, PSA, Ca-19-9) were negative. The kidney biopsy revealed "Extracapillar glomerulonephritis with Ig A depositis in DIF) and the patients received 6 monthly cyclophosphamide pulse.
Our second patient presented initially with acute appendicitis confirmed by the histological finding. There was no depositis in the DIF.
All the patients had complete recovery from their abdominal symptoms within approximately three weeks.
HSP usually presents with a classic tetrad of rash, polyarthralgias, abdominal pain and renal disease. The clinical presentation of HSP is more severe among adult and tends to be atypical: higher rate of severe and atypical GI problems and delayed renal complications .
Older patients showed much more severe renal and extra-renal manifestations than younger patients in which the joint manifestations appear to be the most frequent. However, the severe GI involvements are less common in adults than children [4,5]. The mechanism of GI involvement in HSP may include IgA deposits on small vessel wall and polymorphonuclear neutrophils (PMNs) infiltration around vessels .
It occurs in 50- 75% of adult patients .
In a large Italian cohort of 250 patients, adults and children, with HSP, necrotic purpura was present in 96% of the cases, arthritis in 61% of the cases and GI involvement in 48% of cases. The main symptom was colicky abdominal pain. Bleeding occurred in 51% cases of GI involvement and was serious, requiring transfusion or surgery or leading to death in 11% of the cases .
In the retrospective study conducted by Chang and all, including 261 children with a diagnosis of HSP, 151 (58%) had abdominal pain and 46 (17.6%) had GI bleeding detected as positive stool occult blood. Seven patients had gross bloody stools .
When comparing 82 children and 20 adults with HSP, Uppal and all found that the frequency nausea, vomiting, malena/hematochezia and intussusception were the same in both groups. Adults had a higher frequency of diarrhea .
When studying 46 adults and 116 children with HSP, Blanco and all reported a higher incidence of renal (p < i0.001) and lower GI involvement at disease onset in adult HSP, but during the clinical course, GI involvement was the same in both age groups .
Trouiller and all tried to assess a score of severity proposed to use clinical and radiological (CT scan) severity scores to assess the usefulness and the efficacy of corticosteroid therapy. The authors conclude, by styding 34 cases of patients with HSP, 68% of them with GI involvement, that these results suggest that corticosteroids may reduce abdominal symptoms of HSP in adults with clinically severe disease .
In rare cases, GI involvements revealed HSP, as in our 3 patients. It was reported by Farah  and Moles . Al Toma and all described a case of a 40- year's old man who presented with terminal ileitis complicated by thrombotic microangiopathy revealing HSP .
Another important retrospective study was performed by Chen and Kong including 161 patients; colicky abdominal pain was noticed in 98.1% and vomiting in 39.5% of the patients. In 25 (3%) of the reported cases, GI symptoms were manifested before skin rash .
The classic findings may consist in: Periumbilical colicky and abdominal pain (related to edema, bleeding), nausea, vomiting, diarrhea, constipation, abdominal distension which are usually mils and rarely severe enough to be confused with an acute abdomen leading to laparotomy. Rare GI manifestations may include: Intestinal perforation, ischemic vasculitis, intussusceptions, esophageal ulcers, pancreatitis, pseudomembranous colitis, extensive GI bloodloss requires hemodynamic monitoring, transfusion and occasionally emergent surgical intervention, appendicitis, massive bowel necrosis. Massive GI hemorrhage and grossly bloody or melanotic stools are respectively reported in 2% and 30% of the patients [13,19-22]. Simultaneous occurrence HSP and acute appendicitis is rarely observed, as in our second case .
Mucosal lesions develop anywhere within the GI tract. Diffuse mucosal redness, small ring-like petechiae and hemorrhagic erosions are characteristic endoscopic findings. The small intestine is considered to be the most frequently affected site. Duodenal involvement was more prominent in the second part of the duodenum than in the bulb .
Imaging studies consisting in abdominal X -ray film, abdominal echography, and abdominal CT, and stool occult blood tests are important examinations . Laparotomy which is performed in approximately 10% is useful when esophagogastroduodenoscopy, colonoscopy and small bowel barium radiogram show normal results. Videocapsule endoscopy represents a unique improvement in the investigation of intestinal diseases, allowing an excellent visualization of the mucosa of the small bowel .
Malignancy also has been reported as a rare causative factor of HSP . The recent retrospective study conducted by Mitsui and all found 53 cases of malignant tumors . Our first patient had colic dysplasia. No previous association has been reported so far.
Helicobacter pylori (Hp) infection may be associated with the development and relapse of HSP with gastrointestinal involvement among children; Wang found that 21 of 36 HSP patients with GI manifestations were confirmed with Hp infection (58.3%). Among those patients, the relapsed patients had a Hp positive rate of 81.3% (13/16), which was significantly higher than the newly diagnosed patients (45.0%, 9/20; P < 0.05). Two of our patients had Hp infection at the moment of the diagnosis .
When studying 11 adult patients with HSP and 20 healthy subjects, Novak concluded that IgG antibodies to Hp may be present mostly in acute HSP, while IgA antibodies may be involved in sustaining GI symptoms underlying the chronic phase of the disease .
The cutaneous pathology of Hp is far from being clear, but it is speculated that the systemic effects may involve increased mucosal permeability to alimentary antigens, immunomodulation, an autoimmune mechanism or the impairment of vascular integrity .
Recently, polymorphism at codon 469 of the intercellular adhesion molecule-1 (ICAM-1) locus has been associated with protection against severe gastrointestinal complications in HSP .
In most cases, HSP spontaneously disappears without treatment. The use of corticosteroids is controversial and usually reserved for severe systemic manifestations .
Steroid treatment makes improvement in the GI symptoms at an early stage but does not prevent the recurrence of abdominal pain attacks. Steroids decrease the intestinal wall edema and thus the symptoms improve or disappear.
In a Randomized, Double-Blind, Placebo-Controlled Trial, including 171 patients with HSP, Prednisone was effective in reducing abdominal pain (p = 0,028); the incidence of severe abdominal pain necessitating hospital admission was greater in the placebo group than in the prednisone group . These data are in keeping with those of Peru and all; these authors conclude that the steroid treatment given to HSP patients with GI manifestations might be helpful to prevent probable complications such as bleeding and intussusceptions .
The use of gastric acid secretion inhibitors are also very beneficial on GI involvement.
Colchicina can be used in the treatment of HSP [35,36]. The rationale for using colchicine to treat HSP is based on the fact that colchicine perturbs microtubule function of the polymorphonuclear cell cytoskeleton . This results in inhibition of polymorphonuclear cell migration to the site of inflammation.
GI involvements are frequent in HSP. The diagnosis is more difficult when they precede the other manifestations and especially the cutaneous rash. Treatments are still controversial.
AH: Wrote the manuscript; WM: Done the gastric exploration; OH: participate to the writing of the manuscript; LN: conducted the genetic study; RM: participate to the writing of the manuscript; MS: Participate to the coordination. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
|Nielsen HE,Epidemiology of Schonlein-Henoch purpuraActa Paediatr ScandYear: 19887712513110.1111/j.1651-2227.1988.tb10610.x3369292|
|Shrama A,Wanshu A,Kalra N,Singh S,Bambery P,Successful treatement of severe gastrointestinal involvement in adult- onset Henoch Schonlein PurpuraSingapore Med J Case ReportYear: 200748104750|
|Roberts PF,Waller TA,Brinker TM,Riffe IZ,Sayre J,Bratton RL,Henoch Schonlein purpura: A review articleSouthern Med JYear: 20071008212410.1097/SMJ.0b013e3180f62d0f17713309|
|Blazquez MR,Charlier A,Bognel JC,Manifestations digestives sévères du PR de l'adulteAnn Gastroenterol HepatolYear: 19943058|
|Pillebout E,Thervet E,Hill G,Alberti C,Vanhille P,Nochy D,Henoch-Schonlein Purpura in Adults: Outcome and Prognostic FactorsJ Am Soc NephrolYear: 2002131271127810.1097/01.ASN.0000013883.99976.2211961015|
|Saulsbury FT,Cliniacal update: Henoch Schonlein purpuraLancetYear: 20073699767810.1016/S0140-6736(07)60474-717382810|
|Zhang Y,Huang X,Gastrointestinal involvement in Henoch-Schönlein purpuraScand J GastroenterolYear: 20084310384310.1080/0036552080210186118609159|
|Novák J,Márki-Zay J,Csiki Z,Sebesi J,Takáts A,Sipka S,Schönlein-Henoch purpura in adulthood (gastrointestinal manifestation and endoscopy)Z GastroenterolYear: 2001397758210.1055/s-2001-1719511558068|
|Coppo R,Mazzucco G,Cagnoli L,Lupo An Schena FP,Long term prognosis of Henoch Schonlein nephritis in adult and childrenItalian Group of Renal Immunopathology Collaborative Study on Henoch Schonlein purpura. Nephrol Dial TransplantYear: 19971222772283|
|Chang WL,Yang YH,Lin YT,Chiang BL,Gastrointestinal manifestations in Henoch Schonlein purpura: a review of 261 patientsActa PeadiatrYear: 2004931427143110.1111/j.1651-2227.2004.tb02623.x|
|Uppal SS,Hussain MA,Al-Raqum HA,Namppry MR,Al-Saied K,Al Assousi A,Abraham M,Malaviva AN,Henoch Schönlein's purpura in adults versus children/adolescents: A comparative studyClin Exp RheumatolYear: 200624S263016859592|
|Blanco R,Tobada Martinez VM,Garcia-Fuentes M,Gonzalez-Gay MA,Henoch Schonlein purpura in adulthood and children: Two different expressions of the same syndromeArthritis RheumYear: 1997408596410.1002/art.17804005139153547|
|Trouiller S,André M,Délévaux I,Mahamadi H,Affo C,Abdominal manifestations of Henoch Schonlein purpura in adults: A retrospective study of 23 casesRev Med IntYear: 2009306617010.1016/j.revmed.2009.02.026|
|Farah R,Shay M,Gastrointestinal involvement in Henoch Schonlein purpuraMinerva Gastroenterol DietolYear: 2007532959917912193|
|Moles JR,Del Val A,Morillas J,Gaspar E,Garrigues V,Berenguer J,Gastrointestinal involvement as the first manifestation of Schoenlein-Henoch purpuraRev Esp Enferm DigYear: 19917936121867926|
|Al Toma A,Brink MA,Hagen EC,Henoch-Schönlein purpura presenting as terminal ileitis and complicated by thrombotic microangiopathyEur J Int MedYear: 2005165101210.1016/j.ejim.2005.09.002|
|Trapani S,Micheli A,Grisolia F,resti M,Chiappini E,Falcini F,Martino M,Henoch Schonlein Purpura in Childhood: Epidemiological and Clinical Analysis of 150 Cases Over a 5-year Period and Review of LiteratureSemin Arthritis RheumatolYear: 2005351435310.1016/j.semarthrit.2005.08.007|
|Chen SY,Kong MS,Gastrointestinal manifestations and complications of Henoch Schonlein purpuraChang Gung MedYear: 20042717581|
|Akbar DH,Fatal complication of Henoch Schonlein purpura: Case report and literature reviewSaudi J GastroenterolYear: 20006165819864714|
|Ebert EC,Gastrointestinal manifestations of Henoch-Schonlein PurpuraDis Dig SciYear: 2008532011910.1007/s10620-007-0147-0|
|Passam FH,Diamantis ID,Perisinaki G,Saridaki Z,Kritikos H,Georgopoulos D,Boumpas DT,Intestinal ischemia as the first manifestations of vasculitisSemin Arthirtis RheumYear: 20043443144110.1016/j.semarthrit.2003.12.004|
|Degushi M,Shiraki K,Itoh N,Esophageal involvement in Schonlein Henoch purpuraGastrointestinal EndoscopyYear: 2001532414410.1067/mge.2001.11218311174307|
|Jangjoo A,Amouzeshi A,Jalali AN,Gangrenous appendicitis in a child with Henoch-Schonlein purpuraJournal of Pediatric SurgeryYear: 200843 E33-E35..|
|Esaki M,Takayuki M,shotaro N,Kawasaki M,Iwai K,Hirakawa K,Tarumi KI,Yao T,Lida M,GI involvement in Henoch-Schonlein purpuraGastrointestinal EndoscopyYear: 2002569202310.1016/S0016-5107(02)70376-312447314|
|Stancanelli B,Vita A,Vinci M,Magnano A,Purrello F,Bleeding of small bowel in Henoch Schonlein syndrome: The successful diagnosis role of video capsule endoscopyAm J MedYear: 2006119829010.1016/j.amjmed.2005.05.03416431200|
|Zurada JM,Ward KM,Grossman EM,Henoch Schonlein purpura associated with malignancy in adultsJ Am Acad DermatolYear: 200655S657010.1016/j.jaad.2005.10.01117052537|
|Mitsui H,Shibagaki N,Kawamura T,Matsue H,Shimada S,A clinical study of Henoch-Schönlein Purpura associated with malignancyJ Eur Acad Dermatol VenereolYear: 20092339440110.1111/j.1468-3083.2008.03065.x19207675|
|Wang BH,Zhou LQ,Zuo YH,Relationship between Helicobacter pylori infection and Henoch-Schonlein purpura with gastrointestinal involvement in childrenZhongguo Dang Dai Er Ke Za ZhiYear: 20079367917706043|
|Novák J,Szekanecz Z,Sebesi J,Takáts A,Demeter P,Bene L,Sipka S,Csiki Z,Elevated levels of anti-Helicobacter pylori antibodies in Henoch-Schönlein purpuraAutoimmunityYear: 20033630731110.1080/0891693023200011453514567560|
|Weddi B,Kappa A,Helicobacter pylori infection in skin diseases: a critical appraisalAm J Clin DermatolYear: 20024273282|
|Amoli MM,Mattey DL,Calvino MC,Garcia-Porrua C,Thomson W,Hajeer AH,Ollier WE,Gonzales-Gay MA,Polymorphism at codon 469 of the intercellular adhesion molecule-1locus is associated with protection against severe gastrointestinal complications in Henoch-Schonlein purpuraJ RheumatolYear: 2001281014811361181|
|Yamada Y,Tanaka S,Kobayshi T,Tatsuguchi A,Sakamoto C,Gastrointestinal manifestations in Henoch-Schönlein purpuraNippon RinshoYear: 2008661350618616127|
|Ronkainen J,Koskimies O,Houhala MA,Antikainene M,Merenmies J,Rajante J,Örmala T,Turtinen J,Nuutinen M,Early prednisone therapy in Henoch-Schönlein purpura: a randomized, double-blind, placebo-controlled trialJ PediatrYear: 2006149241710.1016/j.jpeds.2006.03.02416887443|
|Peru H,Soylemezoglu O,Bakkaloglu SC,Elmas S,Bozkaya D,Elmaci AM,Kara F,Buyan N,Hasanoglu E,Henoch Schonlein purpura in childhood: clinical analysis of 254 cases over a 3-year periodClin RheumatolYear: 2008271087109210.1007/s10067-008-0868-218305976|
|Pyne D,Mootoo R,Bhanji A,Colchicine for the treatment of recurrent Henoch-Schönlein purpura in an adultRheumatology (Oxford)Year: 200140121430110.1093/rheumatology/40.12.1430|
|Padeh S,Passwell JH,Successful treatment of chronic Henoch-Schonlein purpura with colchicine and aspirinIsr Med Assoc JYear: 200026482310897246|
|Bar-Eli M,Wilson L,Peters RS,Schwabe AD,Territo M,Microtubules in PMNs from patients with familial Mediterranean feverAm J Med SciYear: 198228422710.1097/00000441-198209000-000017124787|
[Figure ID: F1]
Leucocytoclasic vasculitis of the duodenum.
Clinical, demographic and laboratory findings of the 3 patients
|Feature||Case 1||Case 2||Case 3|
|GI involvment||Hematemesis/abdominal pain||Severe abdominal pain/vomitting||Colicky abdominal pain/vomiting.|
|Skin rash||Lower limb and abdomen||Lower limb||Lower limb|
|Joints involved||Joint tenderness||Arthritis of the knee and ankles||arthritis of the ankle|
|Delay between GI involvement and other symptoms||3 weeks||4 weeks||2 weeks|
|Total leucocyte count (/μL)||13.000||10.400||12.200|
|Platelet count (/μL)||343.000||360.000||371.000|
|ESR (mm/1st hour)||45||22||37|
|Urine microscopy||Microscopc hematuria||Normal||Normal|
|24-hour urinary proteins||3.3 gr||Nil||Nil|
|occult blood stool tests||positive||Not done||negative|
|Colonoscopy||colic poliposis with moderate dysplasia on the biopsy.||Not done||Not done|
|CT of the abdomen||Not done||Normal||Not done|
|Skin biopsy||Leucocytoclastic vasculitis
DIF: Ig A
DIF: Ig A/C3
DIF: Ig A/C3
|Oesogastroduodenal endoscopy/Biopsy||Cardial ulcer with stigmata of bleeding and purpuric lesions of the bulb and the duodenum/presence of leucocytoclastic vasculitis with intestinal metaplasia and Hp gastritis||Antrite congestive with purpuric lesions of the bulb and the duodenum/presence of leucocytoclastic vasculitis with chronic and moderately active Hp antral gastritis||Purpuric lesions of the bulb and ulcers of the DI and DII portion of the bulb/erosive duodenitis and leucocytoclastic vasculitis 1|
|Kidney biopsy||Extracapillar glomerulonephritis with Ig A depositis in DIF||Not done||Not done|
|treatment||Methylprednisolone pulse (1 g/day × 3 days) + oral prednisolone associated with cyclophosphamide pulse||Colchicine®
|Outcome||Complete recovery||Complete recovery||Complete recovery|
ESR: erythrocyte sedimentation rate; HPE: histopathology; DIF: direct immunofluorescence; GI: Gastrointestial ; PPI: proton pump inhibitors; Hp: Helicobacter pylori
Keywords: Adult Henoch Schönlein purpura, Gastrointestinal involvement.
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