| Gastrointestinal involvement in patients with systemic sclerosis. | |
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MedLine Citation:
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PMID: 20424538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Gastrointestinal (GI) involvement is a serious complication of systemic sclerosis (SSc). OBJECTIVES: The aim of the study was to determine the incidence of GI manifestations in SSc. PATIENTS AND METHODS: We studied 73 patients with SSc (60 women and 13 men). Diffuse cutaneous SSc (dcSSc) was diagnosed in 30 patients and limited cutaneous SSc (lcSSc) in 43 patients. Upper GI involvement was assessed based on clinical symptoms such as dysphagia and gastroesophageal reflux-related complications. The majority of patients underwent radiographic examination including a barium swallow. Lower GI involvement was evaluated on the basis of such clinical symptoms as constipation and diarrhea. RESULTS: GI symptoms were observed in 54 (74%) SSc patients. Upper GI symptoms were observed in 54 (74%) patients and lower GI symptoms in 22 (30%) patients. The presence of anticentromere antibodies is associated with a lower risk of GI involvement. There are no significant differences in the incidence of pulmonary involvement between SSc patients with and without GI symptoms. CONCLUSIONS: GI involvement is observed in the majority of SSc patients. Clinical symptoms of GI involvement are significantly more common in patients with dcSSc. The incidence of upper GI symptoms is significantly higher than that of lower GI symptoms. |
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Authors:
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Ewa Wielosz; Olga Borys; Iwona Zychowska; Maria Majdan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Polskie Archiwum Medycyny Wewnętrznej Volume: 120 ISSN: 1897-9483 ISO Abbreviation: Pol. Arch. Med. Wewn. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-07-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401225 Medline TA: Pol Arch Med Wewn Country: Poland |
Other Details:
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Languages: eng Pagination: 132-6 Citation Subset: IM |
Affiliation:
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Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland. ewaw1973@op.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antibodies, Antinuclear / blood Deglutition Disorders / blood, epidemiology*, etiology* Female Gastroesophageal Reflux / blood, epidemiology*, etiology* Humans Incidence Male Middle Aged Scleroderma, Diffuse / blood, complications Scleroderma, Limited / blood, complications Scleroderma, Systemic / blood, complications* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/anticentromere antibody |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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