Document Detail

Gastrointestinal involvement in patients with systemic sclerosis.
MedLine Citation:
PMID:  20424538     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Gastrointestinal (GI) involvement is a serious complication of systemic sclerosis (SSc). OBJECTIVES: The aim of the study was to determine the incidence of GI manifestations in SSc. PATIENTS AND METHODS: We studied 73 patients with SSc (60 women and 13 men). Diffuse cutaneous SSc (dcSSc) was diagnosed in 30 patients and limited cutaneous SSc (lcSSc) in 43 patients. Upper GI involvement was assessed based on clinical symptoms such as dysphagia and gastroesophageal reflux-related complications. The majority of patients underwent radiographic examination including a barium swallow. Lower GI involvement was evaluated on the basis of such clinical symptoms as constipation and diarrhea. RESULTS: GI symptoms were observed in 54 (74%) SSc patients. Upper GI symptoms were observed in 54 (74%) patients and lower GI symptoms in 22 (30%) patients. The presence of anticentromere antibodies is associated with a lower risk of GI involvement. There are no significant differences in the incidence of pulmonary involvement between SSc patients with and without GI symptoms. CONCLUSIONS: GI involvement is observed in the majority of SSc patients. Clinical symptoms of GI involvement are significantly more common in patients with dcSSc. The incidence of upper GI symptoms is significantly higher than that of lower GI symptoms.
Ewa Wielosz; Olga Borys; Iwona Zychowska; Maria Majdan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Polskie Archiwum Medycyny Wewnętrznej     Volume:  120     ISSN:  1897-9483     ISO Abbreviation:  Pol. Arch. Med. Wewn.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401225     Medline TA:  Pol Arch Med Wewn     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  132-6     Citation Subset:  IM    
Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland.
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MeSH Terms
Antibodies, Antinuclear / blood
Deglutition Disorders / blood,  epidemiology*,  etiology*
Gastroesophageal Reflux / blood,  epidemiology*,  etiology*
Middle Aged
Scleroderma, Diffuse / blood,  complications
Scleroderma, Limited / blood,  complications
Scleroderma, Systemic / blood,  complications*
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/anticentromere antibody

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