Document Detail


Gastrointestinal involvement in Henoch-Schönlein purpura.
MedLine Citation:
PMID:  18609159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To analyse the gastrointestinal manifestation of Henoch-Schonlein purpura (HSP) in adult patients, including clinical and endoscopic features. MATERIAL AND METHODS: Patients with a final diagnosis of HSP admitted from January 1995 to January 2006 were included. Their medical records, including clinical presentation, laboratory data, endoscopy and pathology reports, were reviewed retrospectively. RESULTS: One-hundred-and-fifteen patients were included. Gastrointestinal symptoms occurred in 90 patients (78.2%), with abdominal pain the most common symptom. Fifty-four patients underwent gastroscopy, while 24 underwent colonoscopy. The endoscopic lesions included mucosal erythema, oedema, multiple irregular ulcers and nodular changes. In the upper GI tract, the second portion of the duodenum was the most frequently involved area and is where the most severe lesions occur. In the lower GI tract, the rectum was the most frequently involved area, but the most severe lesions were found in the terminal ileum. CONCLUSIONS: HSP may present with acute abdomen without typical skin manifestations, and gastroscopy and colonoscopy can be helpful in the early diagnosis of HSP in these patients. Typical endoscopic findings include diffuse mucosal oedema, erythema, petechia or multiple irregular ulcers, especially in the second portion of the duodenum or in the terminal ileum.
Authors:
Yan Zhang; Xinglan Huang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  43     ISSN:  1502-7708     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-19     Completed Date:  2008-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1038-43     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, China.
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MeSH Terms
Descriptor/Qualifier:
Abdomen, Acute / diagnosis,  etiology
Adult
Age Distribution
Biopsy, Needle
Cohort Studies
Colonoscopy / methods
Comorbidity
Female
Follow-Up Studies
Gastrointestinal Diseases / diagnosis*,  epidemiology*
Gastroscopy / methods
Humans
Immunohistochemistry
Incidence
Intestinal Mucosa / pathology
Male
Purpura, Schoenlein-Henoch / diagnosis*,  epidemiology*
Retrospective Studies
Risk Assessment
Severity of Illness Index
Sex Distribution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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