Document Detail

Gastrointestinal immunopathology and food allergy.
MedLine Citation:
PMID:  15562871     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review the current data that support the pivotal function of the gastrointestinal immune system in health and disease and its critical role in the pathogenesis of a wide variety of clinical disorders associated with food allergy (FA). DATA SOURCES: Internet-based literature search and our own data. STUDY SELECTION: The studies included in this review were selected based on the expert opinion of the authors. RESULTS: In contrast to the beneficial expressions of gastrointestinal-associated lymphoid tissue, which are seen with relevance to newer methods of delivery of vaccines directly applied to the gastrointestinal mucosal surfaces (eg, oral poliovirus, rotavirus, Salmonella typhi vaccines), the adverse consequences of a mucosal immune response gone astray are evidenced in many diseases such as FA. A classification of clinical disorders associated with FA based on classic mechanisms of immunologic injury is presented, which includes the following: (1) IgE-mediated, (2) non-IgE-mediated, and (3) mixed IgE- and non-IgE-mediated disorders. Our study of immunologic disturbance in patients with non-IgE FA revealed a pattern of increased CD4+ and decreased TH1 cell counts in peripheral blood mononuclear cells in contrast to patients with celiac disease, where a pattern of increased CD8+ and TH1 cell counts in peripheral blood mononuclear cells and increased CD8+ cell counts was seen. CONCLUSIONS: The gastrointestinal immune response thus plays a pivotal role in maintaining protective immunity in health and a critical role in the pathogenesis of a wide variety of clinical disorders associated with FA.
Joseph A Bellanti; Aderbal Sabra; Barbara J Zeligs
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  93     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-25     Completed Date:  2004-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S26-32     Citation Subset:  IM    
Department of Pediatrics, the International Center for Interdisciplinary Studies of Immunology, Georgetown University Medical Center, Washington, DC 20007, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Breast / blood supply
Food Hypersensitivity / etiology*
Gastrointestinal Tract / immunology*
Histocompatibility Antigens Class I / immunology
Histocompatibility Antigens Class II / immunology
Immunoglobulin E / blood
Lymphoid Tissue / immunology
Receptors, Antigen, T-Cell / physiology
Reg. No./Substance:
0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II; 0/Receptors, Antigen, T-Cell; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Genetic modification of food allergens.
Next Document:  Current and potential uses of probiotics.