Document Detail

Gastrointestinal hepatoid adenocarcinoma: venous permeation and mimicry of hepatocellular carcinoma, a report of four cases.
MedLine Citation:
PMID:  9253624     Owner:  NLM     Status:  MEDLINE    
AIMS: Four cases of hepatoid adenocarcinoma, three in the stomach, and one in the sigmoid colon, are presented to emphasize venous permeation and mimicry of hepatocellular carcinoma by metastatic liver nodules. METHODS AND RESULTS: Tumour cells in all cases extensively invaded vems, and intravenous tumour thrombi in two cases were grossly observed as anastomosing, worm-like cords up to 10 mm in diameter in the lesser omentum and mesentery in continuity with the primary mucosal lesions. The cytological features and trabecular architecture of the metastatic liver nodules in these subjects mimicked primary hepatocellular carcinoma. In a third case the tumour contained grossly visible bile in a metastatic lung nodule, but there was no evidence of bile production in the primary gastric or metastatic liver lesions. In the fourth case, detailed histopathological study revealed a gastric origin of the hepatoid adenocarcinoma, rather than primary hepatocellular carcinoma metastatic to the stomach, the initial diagnosis. CONCLUSIONS: These cases are reported here to draw attention to this rare variant of gastrointestinal adenocarcinoma, its mimicry of hepatocellular carcinoma when metastatic to the liver and other sites, and its propensity for venous permeation.
H Ishikura; T Kishimoto; H Andachi; Y Kakuta; T Yoshiki
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Histopathology     Volume:  31     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-16     Completed Date:  1997-09-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
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MeSH Terms
Adenocarcinoma / pathology*,  secondary
Carcinoma, Hepatocellular / pathology*
Diagnosis, Differential
Middle Aged
Neoplastic Cells, Circulating / pathology
Sigmoid Neoplasms / pathology*
Stomach Neoplasms / pathology*,  secondary

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