| Gastrointestinal glutathione peroxidase. | |
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MedLine Citation:
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PMID: 10609889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gastrointestinal glutathione peroxidase (GI-GPx) is the fourth member of the GPx family. In rodents, it is exclusively expressed in the gastrointestinal tract, in humans also in liver. It has, therefore, been discussed to function as a primary barrier against the absorption of ingested hydroperoxides. A vital function of GI-GPx can be deduced from the unusual stability of its mRNA under selenium-limiting conditions, the presence of low amounts of GI-GPx protein in selenium deficiency where cGPx is absent, and the fast reappearance of the GI-GPx protein upon refeeding of cultured cells with selenium compared to the slower reappearance of cGPx protein. Furthermore, the Secis efficiency of GI-GPx is low when compared to cGPx and PHGPx. It is, however, almost independent of the selenium status of the cells tested. All these characteristics rank GI-GPx high in the hierarchy of selenoproteins and point to a role of GI-GPx which might be more crucial than that of cGPx, at least in the gastrointestinal system. |
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Authors:
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K Wingler; R Brigelius-Flohé |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: BioFactors (Oxford, England) Volume: 10 ISSN: 0951-6433 ISO Abbreviation: Biofactors Publication Date: 1999 |
Date Detail:
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Created Date: 2000-02-01 Completed Date: 2000-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8807441 Medline TA: Biofactors Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 245-9 Citation Subset: IM |
Affiliation:
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German Institute of Human Nutrition, Potsdam-Rehbrücke, Institute of Nutritional Science, University of Potsdam. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromosome Mapping Chromosomes, Human, Pair 14* Digestive System / enzymology* Gene Expression Regulation, Enzymologic / drug effects Glutathione Peroxidase / genetics*, metabolism* Humans Pseudogenes RNA, Messenger / genetics Selenium / metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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