Document Detail

Gastrointestinal factors in nausea and vomiting of pregnancy.
MedLine Citation:
PMID:  12011886     Owner:  NLM     Status:  MEDLINE    
The objective of this review is to outline gastrointestinal factors that may be relevant to nausea and vomiting of pregnancy. Gastric neuromuscular dysfunctions of the stomach include abnormalities in gastric myoelectrical activity, gastric tone, and contractility, all of which may result in gastroparesis. These abnormalities in gastric neural activity and smooth muscle function are associated with nausea and vomiting in nonpregnant patients. Gastric dysrhythmias are disturbances of gastric pacesetter potential patterns that are present during the nausea of motion sickness, drug-induced nausea, in patients with diabetic gastropathy, and women with nausea of pregnancy. In pregnant women with abdominal pain, nausea, and vomiting, standard gastrointestinal diseases such as gastroesophageal reflux, peptic ulcers, and cholecystitis must be considered. A diagnostic approach and therapeutic options for treating nausea and vomiting of pregnancy based on understanding of gastric neuromuscular dysfunction is outlined.
Kenneth L Koch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  186     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S198-203     Citation Subset:  AIM; IM    
Division of Gastroenterology and Hepatology, The Milton S. Hershey Medical Center, The Pennsylvania State University, 17033-0850, USA.
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MeSH Terms
Intestines / physiology*
Nausea / etiology*,  therapy
Neuromuscular Junction / physiology
Pregnancy Complications / etiology*,  therapy
Stomach / physiology*
Vomiting / etiology*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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