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Gastrointestinal complications associated with ibuprofen therapy for patent ductus arteriosus.
MedLine Citation:
PMID:  21252965     Owner:  NLM     Status:  Publisher    
Objective:To review intestinal complications associated with ibuprofen treatment of patent ductus arteriosus (PDA).Study Design:Data from preterm infants treated with ibuprofen were retrospectively reviewed. χ (2) test and Fischer's exact test were used for univariate analyses. Multivariate analyses with logistic regression modeling were used to identify risk factors.Result:One hundred and two infants were treated with ibuprofen for PDA. Nine (9/102, 8.8%) infants developed spontaneous intestinal perforation (SIP), whereas 93/102 (91.2%) did not. The mean (±s.d.) gestational age (GA) at birth in infants with and without SIP was 25.2 (±1.3) vs 27.6 (±2.4) weeks (P=0.02) and the median (interquartile) length of stay (LOS) was 109.5 (91.0 to 116.5) vs 75.0 (53.0 to 94.5) days (P=0.002), respectively. The mean (±s.d.) age at starting ibuprofen was 3.3 (±1.3) vs 5.8 (±3.5) days in infants with and without SIP, respectively (P=0.03). In logistic regression analyses, increasing GA and later initiation of ibuprofen treatment were protective against risk of SIP; odds ratio, 95% confidence interval (OR, 95% CI)=0.26 (0.09 to 0.75), P=0.01 and 0.63 (0.41 to 0.95), P=0.03, respectively.Conclusion:Infants at lower GA are at risk of SIP when treated early with ibuprofen for symptomatic PDA.Journal of Perinatology advance online publication, 20 January 2011; doi:10.1038/jp.2010.199.
R Rao; K Bryowsky; J Mao; D Bunton; C McPherson; A Mathur
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-20
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Newborn Medicine, Washington University in St Louis, St Louis, MO, USA.
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