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Gastrointestinal bleeding associated with antithrombotic therapy in the elderly in Japan.
MedLine Citation:
PMID:  22469720     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background/Aims: We summarize data of patients with gastrointestinal bleeding (GIB) and discuss the relationship between antithrombotic drug use and age in patients with GIB. Methodology: One-hundred and twenty patients with GIB were divided into two groups according to age (=75 years old and <75 years old). The causes and clinical outcome of each group were compared. Results: Forty-two patients received antithrombotic therapy. The main antithrombotic drugs were low dose aspirin (38 patients), ticlopidine (5 patients) and warfarin (3 patients). Compared with younger GIB patients, elderly patients had more coexisting illness and antithrombotic drugs. In patients taking antithrombotic drugs, upper GIB is more frequent than those not taking antithrombotic drugs (p<0.05) and antithrombotic drugs were the risk for GIB from erosive lesions of the esophagus or stomach. In the lower gastrointestinal tract, there was no difference of incidence related to antithrombotic use. The initial endoscopic hemostasis was performed in 14 patients. Eight varices patients received endoscopic vanding and 6 of 43 gastroduodenal ulcer patients had mechanical clip hemostasis. Conclusions: From our findings, antithrombotic drugs were considered to be a risk for GIB. It might be important to prevent or minimize GIB in elderly patients prescribed antithrombotic drugs.
Authors:
Taketoshi Suehiro; Yoichi Yakeishi; Fumitaka Sakai; Koichi Matsuzaki; Kensaku Sanefuji; Tsuyoshi Toyokawa; Kei Shioshita; Yumi Sugie; Yasuyuki Okudaira; Tadashi Kano; Hiroyuki Mine; Keiko Suetsugu; Fuminaga Suetsugu; Naohisa Suehiro; Kikuo Suhiro
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  59     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2012 May-Jun
Date Detail:
Created Date:  2012-04-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  774-7     Citation Subset:  IM    
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