Document Detail

Gastrointestinal adaptation to diets of differing fat composition in human volunteers.
MedLine Citation:
PMID:  2040469     Owner:  NLM     Status:  MEDLINE    
The effect of a low fat diet (9 MJ) v a high fat diet (19.26 MJ), each consumed separately for four and 14 days, on gastric emptying and mouth to caecum transit time of a high fat test meal and body weight and satiety were examined in groups of 10 and six normal male volunteers. The half time for gastric emptying (t1/2) and the mouth to caecum transit time of a high fat test meal was significantly faster after the high fat diet than the low fat diet when consumed for 14 days (t1/2=98 (80-116) v 147 (88-206) minutes (median (range)), p less than 0.05; mouth to caecum transit time 240 (130-350) v 360 (200-520) minutes, p less than 0.05), but not when consumed for only four days. The mean (SEM) body weight of all subjects significantly increased during the 14 day high fat diet (74.7 (1.3) v 72.7 (1.6) kg, p less than 0.05) but was not influenced during the consumption of the low fat diet. When subjects were given an appetising meal to consume on the day that they had consumed the transit test meal, they ate similar amounts irrespective of their recent dietary history, though the eating rate was significantly slower after the high fat diet (mean (SEM)) 46.7 (1.9) v 71.3 (14.8)/min, p less than 0.05). Maintaining normal subjects on a high or low fat diet for two weeks resulted in a desensitisation or sensitisation respectively of the mechanisms by which nutrients regulate gastrointestinal transit. These findings emphasise the importance of the recent dietary history in the interpretation of gastric emptying and small bowel transit time data.
K M Cunningham; J Daly; M Horowitz; N W Read
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  32     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-07-10     Completed Date:  1991-07-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  483-6     Citation Subset:  AIM; IM    
Sub-Department of Human Gastrointestinal Physiology and Nutrition, Royal Hallamshire Hospital, Sheffield.
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MeSH Terms
Adaptation, Physiological / physiology*
Body Weight
Dietary Fats / administration & dosage*
Eating / physiology
Gastric Emptying / physiology
Gastrointestinal Motility / physiology*
Gastrointestinal Transit / physiology
Intestine, Small / physiology
Time Factors
Reg. No./Substance:
0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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