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Gastrointestinal Mesenchymal Neoplasms other than Gastrointestinal Stromal Tumors: Focusing on Their Molecular Aspects.
MedLine Citation:
PMID:  21403834     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Gastrointestinal (GI) mesenchymal tumors other than gastrointestinal stromal tumor (GIST) are rare neoplasms, but they often enter the differential diagnosis of more common GI lesions. Some of these mesenchymal tumors in the GI tract have well understood molecular pathologic aspects, including desmoid tumors, inflammatory myofibroblastic tumor (IMT), clear cell sarcoma (CCS), inflammatory fibroid polyp (IFP), and synovial sarcoma (SS). Molecular pathology is fast becoming a mainstream focus in laboratories because it aids in the precise classification of tumors, may be prognostic, and may help predict response to therapy. The following review is not intended as an exhaustive summary of all mesenchymal tumors that have been reported to involve the GI tract, but instead will highlight the current knowledge of the most important non-GIST GI mesenchymal neoplasms, focusing on those tumors with well-characterized molecular pathology and how the molecular pathologic features impact current diagnostic, therapeutic, and prognostic standards.
Authors:
Thomas P Plesec
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Publication Detail:
Type:  Journal Article     Date:  2011-02-16
Journal Detail:
Title:  Pathology research international     Volume:  2011     ISSN:  2042-003X     ISO Abbreviation:  Patholog Res Int     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-07-14     Revised Date:  2011-07-26    
Medline Journal Info:
Nlm Unique ID:  101526292     Medline TA:  Patholog Res Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  952569     Citation Subset:  -    
Affiliation:
Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA.
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