Document Detail

Gastrointestinal Kaposi's sarcoma in patients with acquired immunodeficiency syndrome. Endoscopic and autopsy findings.
MedLine Citation:
PMID:  4007399     Owner:  NLM     Status:  MEDLINE    
Homosexual men with acquired immunodeficiency syndrome and Kaposi's sarcoma (KS) have been studied to define the extent of gastrointestinal KS. In 50 patients examined by both upper endoscopy and flexible fiberoptic sigmoidoscopy, 20 (40%) had visible lesions consistent with KS. Ten patients (20%) had upper and lower tract involvement, 6 (12%) patients had upper tract involvement alone, and 4 (8%) had lower tract disease alone. Only 23% of endoscopic biopsies of KS lesions were positive for KS. Gastrointestinal KS was not more frequent in patients with nodal KS (41%) than in patients with skin KS (50%). No clinical sequelae of gastrointestinal KS lesions were seen. Mortality was significantly greater in those patients with endoscopic evidence of gastrointestinal KS. Postmortem examination of 13 men with KS and acquired immunodeficiency syndrome revealed abdominal visceral involvement in 10 patients (77%). Antemortem endoscopic findings correlated with subsequent autopsy data in 5 patients. Our findings suggest that visceral involvement, though rarely symptomatic, may be associated with a poorer prognosis.
S L Friedman; T L Wright; D F Altman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  89     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-07-31     Completed Date:  1985-07-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  102-8     Citation Subset:  AIM; IM; X    
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications*
Colon, Sigmoid / pathology
Gastrointestinal Neoplasms / pathology*
Liver / pathology
Sarcoma, Kaposi / etiology,  mortality,  pathology*
Grant Support

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