Document Detail

Gastroesophageal reflux in patients with sleep apnea syndrome.
MedLine Citation:
PMID:  8585249     Owner:  NLM     Status:  MEDLINE    
Gastroesophageal reflux (GER) may be associated with pulmonary diseases. The aim of this study was to investigate the role of GER in patients with sleep apnea syndrome (SAS). We evaluated, therefore, in patients with SAS the occurrence of GER during simultaneous apnea monitoring, and whether GER is related to the severity of SAS. METHODS: 17 consecutive patients with proven SAS were divided into two groups according to the severity of SAS: (A) apnea index > or = 5 and < 15, n = 8; (B) apnea index > or = 15, n = 9. All patients underwent 24 hours pH-metry in the proximal and distal esophagus and simultaneous apnea monitoring during the night. RESULTS: There was a high occurrence of GER in patients with SAS, but no significant difference was found between the two groups with respect to reflux times at the distal or at the proximal esophageal site. Reflux episodes and apnea periods were not timely correlated. Most of the patients of both groups were obese. CONCLUSIONS: Patients with SAS often have GER. However, there is neither a relation of GER with the severity of SAS nor a timely association between GER- and SAS-episodes. Thus, it is unlikely that there is a direct link between GER and SAS. However, there may be factors predisposing for both diseases.
K I Graf; M Karaus; S Heinemann; S Körber; P Dorow; K E Hampel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zeitschrift für Gastroenterologie     Volume:  33     ISSN:  0044-2771     ISO Abbreviation:  Z Gastroenterol     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-03-21     Completed Date:  1996-03-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0033370     Medline TA:  Z Gastroenterol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  689-93     Citation Subset:  IM    
Department of Internal Medicine, Virchow-Klinikum, Humboldt-Universität zu Berlin, Germany.
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MeSH Terms
Esophagogastric Junction / physiopathology
Gastric Acidity Determination*
Gastroesophageal Reflux / complications,  diagnosis,  physiopathology*
Middle Aged
Sleep Apnea Syndromes / complications,  diagnosis,  physiopathology*

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