| Gastroesophageal reflux in cirrhotic patients without esophageal varices. | |
| | |
MedLine Citation:
|
PMID: 21483637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To evaluate the esophageal motility and abnormal acid and bile reflux incidence in cirrhotic patients without esophageal varices (EV). METHODS: Seventy-eight patients with liver cirrhosis without EV confirmed by upper gastroesophageal endoscopy and 30 healthy control volunteers were prospectively enrolled in this study. All the patients were evaluated using a modified protocol including Child-Pugh score, upper gastrointestinal endoscopy, esophageal manometry, simultaneous ambulatory 24-h esophageal pH and bilirubin monitoring. All the patients and volunteers accepted the manometric study. RESULTS: In the liver cirrhosis group, lower esophageal sphincter pressure (LESP, 15.32 ± 2.91 mmHg), peristaltic amplitude (PA, 61.41 ± 10.52 mmHg), peristaltic duration (PD, 5.32 ± 1.22 s), and peristaltic velocity (PV, 5.22 ± 1.11 cm/s) were all significantly abnormal in comparison with those in the control group (P < 0.05), and LESP was negatively correlated with Child-Pugh score. The incidence of reflux esophagitis (RE) and pathologic reflux was 37.18% and 55.13%, respectively (vs. control, P < 0.05). And the incidence of isolated abnormal acid reflux, bile reflux and mixed reflux was 12.82%, 14.10% and 28.21% in patients with liver cirrhosis without EV. CONCLUSION: Cirrhotic patients without EV presented esophageal motor disorders and mixed acid and bile reflux was the main pattern; the cirrhosis itself was an important causative factor. |
| | |
Authors:
|
Jun Zhang; Pei-Lin Cui; Dong Lv; Shi-Wei Yao; You-Qing Xu; Zhao-Xu Yang |
Related Documents
:
|
7587487 - Endoscopic polypectomy for pacemaker patients. 18351357 - Ct colonography with reduced bowel preparation after incomplete colonoscopy in the elde... 6606327 - The fluoroscopic barium enema in colonic polyp detection. 16024927 - Symptoms and pathophysiological correlations in patients with constipation and function... 6794767 - Position of patient and respiratory function in immediate postoperative period. 9853647 - Serum carnitine levels in epileptic children before and during treatment with valproic ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-04-12 Completed Date: 2011-07-20 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
|
Languages: eng Pagination: 1753-8 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Bilirubin / metabolism Esophageal Motility Disorders / etiology*, physiopathology Esophageal and Gastric Varices / etiology* Esophagus / physiopathology* Female Gastroesophageal Reflux / etiology*, physiopathology Humans Hydrogen-Ion Concentration Liver Cirrhosis / complications* Male Manometry Middle Aged Young Adult |
| Chemical | |
Reg. No./Substance:
|
635-65-4/Bilirubin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Carbachol promotes gastrointestinal function during oral resuscitation of burn shock.
Next Document: Association between polymorphism rs6983267 and gastric cancer risk in Chinese population.