| Gastroesophageal reflux disease and sleep disorders: evidence for a causal link and therapeutic implications. | |
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MedLine Citation:
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PMID: 20535322 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Gastroesophageal reflux disease (GERD) and sleep disturbances are both common health problems. There is a significant association between disturbed sleep and GERD, and this may be bidirectional. Sleep disorders may induce gastrointestinal (GI) disturbances, while GI symptoms also may provoke or worsen sleep derangements. Reflux of gastric acid is a less frequent event during sleep, however, acid clearance mechanisms (including swallowing, salivation and primary esophageal motility) are impaired during sleep resulting in prolongation of acid contact time. Nighttime reflux can lead to sleep disturbance and sleep disturbance may further aggravate GERD by prolonged acid contact time and heightened sensory perception. This may facilitate the occurrence of complicated GERD and decreased quality of life. However, the interplay between sleep problems and GERD is complex, and there are still relatively limited data on this issue. Further investigation of sleep-related GERD may identify common pathophysiological themes and new therapeutic targets. |
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Authors:
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Hye-Kyung Jung; Rok Seon Choung; Nicholas J Talley |
Publication Detail:
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Type: Journal Article Date: 2010-01-31 |
Journal Detail:
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Title: Journal of neurogastroenterology and motility Volume: 16 ISSN: 2093-0887 ISO Abbreviation: J Neurogastroenterol Motil Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-06-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101530189 Medline TA: J Neurogastroenterol Motil Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 22-9 Citation Subset: - |
Affiliation:
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School of Medicine, Ewha Womans University, Seoul, Korea. |
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