| Gastroesophageal reflux disease and Helicobacter pylori: lack of influence of infection on oesophageal manometric, 3-hour postprandial pHmetric and endoscopic findings. | |
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MedLine Citation:
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PMID: 16400350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the relationship between Helicobacter pylori and gastro-oesophageal reflux disease according to manometric and pHmetric findings. METHOD: Fifty-nine consecutive patients with reflux symptoms and endoscopic evidence of mild oesophagitis, were recruited. Manometry and ambulatory pHmetry were performed in all patients, as well as the 3-hour postprandial pHmetry, as a more flexible and well tolerable test. RESULTS: There were no significant differences between Helicobacter pylori positive and negative patients regarding age, sex ratio and endoscopic severity of oesophagitis. There was no difference in prevalence of abnormal oesophageal peristalsis between the two groups (Fisher's exact test, p=NS). Differences were also not found regarding lower oesophageal sphincter pressure between the two groups (mean PLOS 12.86+/-4.39 mmHg and 13.1+/-4.61 mmHg respectively; p=0.840). Finally, the mean values of DeMeester score were 60.38+/-48.04 and 67.64+/-51.04 respectively (p=0.576). CONCLUSION: Helicobacter pylori infection does not influence oesophageal peristalsis, the lower oesophageal sphincter pressure and the acidity of refluxates into the oesophageal lumen, in patients with established gastro-oesophageal reflux disease (esophagitis grade A and B). |
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Authors:
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John Moschos; George Kouklakis; Nikolaos Lyratzopoulos; Eleni Efremidou; Eustratios Maltezos; George Minopoulos |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Romanian journal of gastroenterology Volume: 14 ISSN: 1221-4167 ISO Abbreviation: Rom J Gastroenterol Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2006-01-09 Completed Date: 2006-02-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9315667 Medline TA: Rom J Gastroenterol Country: Romania |
Other Details:
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Languages: eng Pagination: 351-5 Citation Subset: IM |
Affiliation:
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Medical School Democritus University of Thrace, Alexandroupolis, Greece. gut@in.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Endoscopy, Gastrointestinal* Esophagus* / metabolism, pathology, physiopathology Female Gastric Acid / metabolism Gastroesophageal Reflux / complications*, pathology, physiopathology Helicobacter Infections / complications*, pathology, physiopathology Humans Hydrogen-Ion Concentration Male Manometry Middle Aged Postprandial Period / physiology* Risk Factors Severity of Illness Index |
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