Document Detail

Gastroesophageal reflux and cow's milk allergy in infants: a prospective study.
MedLine Citation:
PMID:  8613639     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent reports have suggested that gastroesophageal reflux in pediatric patients may be caused by food allergy. OBJECTIVE: The aim of our study was to determine the frequency of the association of gastroesophageal reflux with cow's milk protein allergy in patients win the first year of life. METHODS: We studied 204 consecutive patients (median age, 6.3 months) who had been diagnosed as having gastroesophageal reflux on the basis of 24-hour continuous pH monitoring and histologic examination of the esophageal mucosa. RESULTS: Clinical history suggested diagnosis of cow's milk allergy in 19 infants, and 93 others had positive test results (serum IgE anti-lactoglobulin, prick tests, circulating or fecal or nasal mucus eosinophils) but did not have symptoms indicating cow's milk allergy. The cow's milk-free diet and two successive blind challenges confirmed the diagnosis of cow's milk allergy in 85 of the 204 patients with gastroesophageal reflux. The clinical presentations of the infants with gastroesophageal reflux alone were different, in view of the greater frequency of diarrhea (p less than 0.0001) and atopic dermatitis (p less than 0.0002). In all, gastroesophageal reflux was associated with, and probably caused by cow's milk allergy, in 85 of 204 cases (41.8%). CONCLUSIONS: Considering the frequency of this association, patients younger than 12 months old with symptoms of gastroesophageal reflux should be carefully examined to determine whether this disorder is primary or caused by cow's milk allergy.
G Iacono; A Carroccio; F Cavataio; G Montalto; I Kazmierska; D Lorello; M Soresi; A Notarbartolo
Related Documents :
9655569 - Reproductive performance, calf growth, and milk production of first-calf heifers sired ...
10589009 - Transforming growth factor-beta in breast milk: a potential regulator of atopic disease...
8045809 - Amaranthus retroflexus (redroot pigweed) poisoning in cattle.
14690209 - Foal-related risk factors associated with development of rhodococcus equi pneumonia on ...
14657879 - Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune respon...
19218419 - Hierarchical oligonucleotide primer extension as a time- and cost-effective approach fo...
17254399 - The east flanders prospective twin survey (efpts).
21044299 - Learn 2 move 0-2 years: effects of a new intervention program in infants at very high r...
878139 - Ophthalmia neonatorum associated with maternal chlamydial infections.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  97     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-06-03     Completed Date:  1996-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  822-7     Citation Subset:  AIM; IM    
Second Divisione Pediatria, Ospedale G. di Cristina, Universita di Palermo, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diagnosis, Differential
Gastroesophageal Reflux / complications,  diagnosis*,  immunology
Hydrogen-Ion Concentration
Infant, Newborn
Milk Hypersensitivity / complications,  diagnosis*,  immunology
Monitoring, Immunologic
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Allergens in Hymenoptera venom. XXVII: bumblebee venom allergy and allergens.
Next Document:  Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 res...