Document Detail

Gastroesophageal and laryngopharyngeal reflux detected by 24-hour combined impedance and pH monitoring in healthy Chinese volunteers.
MedLine Citation:
PMID:  21615870     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To define the normative data of gastroesophageal reflux (GER) and laryngopharyngeal reflux (LPR) in healthy Chinese volunteers.
METHODS: Healthy volunteers without gastrointestinal and throat disease and symptoms were enrolled and underwent 24-hour impedance-pH monitoring.
RESULTS: A total of 37 healthy volunteers completed all the tests (female 54.1%; age 38.0±15.2 years). Of 1862 GER, 49.6% were mixed, 40.9% were liquid and 9.5% were gas. More than half (54.9%) were acid. The median and 95th percentile numbers of GER were 52 and 71, respectively. The number of LPR was eight, of which two were mixed and the others were liquid. Only one episode of reflux was classified as acid LPR. The median and 95th percentile numbers of LPR were 0 and 2, respectively. More liquid reflux were associated with LPR (P=0.02). Age had no influence on GER and LPR reflux profiles.
CONCLUSIONS: Few LPR occurred in healthy Chinese volunteers and they were rarely acid when they reached the larynx. LPR was mostly associated with liquid reflux.
An Jiang Wang; Mao Jin Liang; Ai Yun Jiang; Jin Kun Lin; Ying Lian Xiao; Sui Peng; Jie Chen; Wei Ping Wen; Min Hu Chen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of digestive diseases     Volume:  12     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-27     Completed Date:  2011-09-30     Revised Date:  2013-12-10    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  173-80     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
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MeSH Terms
Asian Continental Ancestry Group*
Electric Impedance
Esophageal pH Monitoring* / instrumentation
Gastroesophageal Reflux / diagnosis*,  physiopathology
Healthy Volunteers
Laryngopharyngeal Reflux / diagnosis*,  physiopathology
Middle Aged
Monitoring, Ambulatory / methods*
Retrospective Studies
Young Adult

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