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Gastroesophageal Reflux Disease in Pregnancy.
MedLine Citation:
PMID:  11177684     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Gastroesophageal reflux disease (GERD) in pregnancy presents a special challenge for the clinician, predominantly because of the potential side effects of pharmacologic interventions on the fetus. Lifestyle and dietary modifications, change in sleeping posture, and antacid medications are emphasized, as these options pose little risk to the fetus. When these interventions are not successful, sucralfate, a mucosal protectant with little to no systemic absorption, should be considered next. Therapy with H(2) receptor antagonists or proton pump inhibitors can be considered in patients with refractory symptoms; though not approved for this use, they are likely safe, particularly in third trimester. Prokinetic agents should be used with extreme caution or avoided altogether in the pregnant patient.
Authors:
Mohan Charan; Philip O. Katz
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Current treatment options in gastroenterology     Volume:  4     ISSN:  1534-309X     ISO Abbreviation:  Curr Treat Options Gastroenterol     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-Feb-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815941     Medline TA:  Curr Treat Options Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  73-81     Citation Subset:  -    
Affiliation:
Division of Gastroenterology, Department of Medicine, The Graduate Hospital, 1800 Lombard Street, Suite 501, Philadelphia, PA 19146, USA.
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