| Gastroesophageal junction: structure and function as assessed by using MR imaging. | |
| | |
MedLine Citation:
|
PMID: 20713610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To develop and validate magnetic resonance (MR) imaging protocols for quantitative assessment of the structural and functional properties of the gastroesophageal junction (GEJ) and to compare MR imaging detection of reflux events against concurrent manometry as a reference method. MATERIALS AND METHODS: The local ethics committee approved this study, and written informed consent was obtained. Twelve healthy volunteers were examined. Three-dimensional models of the GEJ and proximal portion of the stomach were reconstructed from high-spatial-resolution anatomic MR images to assess the insertion angle of the esophagus into the stomach and proximal stomach distention before and after ingestion of a large test meal. A linear mixed-effects model was used to detect differences in the insertion angle and proximal stomach distention with respect to the respiratory cycle and gastric filling. Additionally, dynamic MR imaging at high temporal resolution was used to detect reflux events. RESULTS: The esophageal insertion angle, given in units of plane angle (radians), was more acute in expiration than in inspiration (0.57 vs 0.73 radian, P = .004) but was not affected by feeding. Progressive distention of the proximal stomach was observed from baseline compared with the postprandial period (0.95 vs 0.65 radian(-1), P < .05). Eighteen reflux events detected by using MR imaging were also detected by using manometry. CONCLUSION: MR imaging methods were developed and validated for the assessment of GEJ structure and function (a) to describe the effects of respiration and feeding on the reflux barrier and (b) to detect reflux events in real time. Anatomic and dynamic MR imaging may be useful techniques in the assessment of GEJ physiology and reflux. |
| | |
Authors:
|
Jelena Curcic; Mark Fox; Elad Kaufman; Zsofia Forras-Kaufman; Geoffrey S Hebbard; Shammodip Roy; Anupam Pal; Werner Schwizer; Michael Fried; Reto Treier; Peter Boesiger |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2010-08-16 |
Journal Detail:
|
Title: Radiology Volume: 257 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-20 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
|
Languages: eng Pagination: 115-24 Citation Subset: AIM; IM |
Affiliation:
|
Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology, Zurich, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Esophagogastric Junction / anatomy & histology*, physiology* Female Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Linear Models Magnetic Resonance Imaging / methods* Male Manometry Reference Values |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quantitative analysis of clinical dynamic contrast-enhanced MR imaging for evaluating treatment resp...
Next Document: Does coronary calcium score predict future cardiac function? Association of subclinical atherosclero...