Document Detail


Gastroenteropancreatic hormonal changes during exercise.
MedLine Citation:
PMID:  6108073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral plasma concentrations of gastroenteropancreatic peptides were measured during a 3-h period of bicycle exercise at 40% of maximal oxygen uptake in six normal men. Marked increases (P < 0.02) were found in vasoactive intestinal polypeptide (VIP) [1.8 +/- 0.7 (rest) vs. 22.3 +/- 5.4 pmol x l-1 (mean +/- SE) (3 h)], secretin (0.5 +/- 0.5 vs. 11.1 +/- 2.7 pmol x l-1), pancreatic polypeptide (PP) (4.0 +/- 1.5 vs. 46.3 +/- 11.5 pmol x l-1), somatostatin (SRIF) (12.8 +/- 1.2 vs. 17.7 +/- 0.6 pmol x l-1), whereas no changes occurred in gastric inhibitory polypeptide (37.3 +/- 5.9 vs. 39.2 +/- 9.8 pmol x l-1). Immunoreactive insulin and C-peptide decreased from 0.08 +/- 0.004 and 0.39 +/- 0.03 pmol x l-1, respectively, to 0.04 +/- 0.003 (P < 0.005) and 0.13 +/- 0.02 (P < 0.001). The significant decrease in C-peptide and in the C-peptide-to-insulin molar ratio indicate decreased insulin secretion and clearance, respectively, during exercise. Plasma glucose decreased [5.0 +/- 0.1 (rest) vs. 4.2 +/- 0.3 mmol.l-1 (3 h)] (P < 0.01). During 3 h of rest, none of the measured parameters had changed. The marked exercise-induced changes in plasma concentrations of PP, secretin, VIP, and SRIF are provocative. We know in detail neither the stimuli for the release of these peptides nor their physiological role during exercise.
Authors:
J Hilsted; H Galbo; B Sonne; T Schwartz; J Fahrenkrug; O B de Muckadell; K B Lauritsen; B Tronier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  239     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G136-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Glucose / metabolism
C-Peptide / blood*
Gastrointestinal Hormones / blood*
Humans
Insulin / blood*
Male
Peptides / blood*
Physical Exertion*
Secretin / blood*
Somatostatin / blood
Time Factors
Vasoactive Intestinal Peptide / blood*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 0/Gastrointestinal Hormones; 0/Peptides; 11061-68-0/Insulin; 1393-25-5/Secretin; 37221-79-7/Vasoactive Intestinal Peptide; 51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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