Document Detail

Gastroenteritis with severe consequences: a case of sotalol-induced torsades de pointes.
MedLine Citation:
PMID:  20128168     Owner:  NLM     Status:  MEDLINE    
We present a case of sotalol-induced prolongation of the QT-interval with torsades de pointes in an octogenarian who was hospitalized because of gastroenteritis causing prerenal acute renal failure. Subsequent accumulation of sotalol caused a severe prolongation of the QT-interval on the surface ECG and ultimately torsades de pointes with loss of consciousness. The patient was successfully treated with temporary cardiac pacing, intravenous magnesium sulfate and definitive withdrawal of sotalol. The electrophysiological basis of the pro-arrhythmic properties of sotalol is reviewed in brief, additional risk factors are identified and treatment is outlined.
Vincent Michiels; Hielko Miljoen; Christiaan Vrints
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta cardiologica     Volume:  64     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  839-42     Citation Subset:  IM    
Dept. of Cardiology, Antwerp University Hospital, Antwerp, Belgium.
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MeSH Terms
Aged, 80 and over
Anti-Arrhythmia Agents / adverse effects*,  therapeutic use
Aortic Valve Insufficiency / drug therapy
Bumetanide / adverse effects
Cardiac Pacing, Artificial
Dehydration / etiology
Diuretics / adverse effects
Gastroenteritis / complications*
Heart Conduction System / drug effects
Kidney / drug effects
Kidney Failure, Acute / etiology*
Respiration, Artificial
Sotalol / adverse effects*,  therapeutic use
Torsades de Pointes / chemically induced*,  therapy
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Diuretics; 28395-03-1/Bumetanide; 3930-20-9/Sotalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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