Document Detail


Gastroenteric hormone responses to hedonic eating in healthy humans.
MedLine Citation:
PMID:  23312063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hedonic eating differentiates from homeostatic eating on two main aspects: the first one is that eating occurs when there is no need for calorie ingestion and the second one is that the food is consumed exclusively for its gustatory and rewarding properties. Gastroeneteric hormones such as ghrelin, colecystokinin-33 (CCK) and peptide YY3-36 (PYY3-36) are known to play a pivotal role in the homeostatic control of food intake. To the contrary, their role in hedonic eating has been never investigated. Here we report peripheral responses of CCK, PYY3-36 and ghrelin to the consumption of food for pleasure in well-nourished satiated healthy subjects. Plasma levels of CCK, PYY3-36 and ghrelin were measured in 7 satiated healthy subjects before and after ad libitum consumption of both a highly pleasurable food (hedonic eating) and an isoenergetic non-pleasurable food (non-hedonic eating). The consumption of food for pleasure was associated to a significantly increased production of the hunger hormone ghrelin and a significantly decreased secretion of the satiety hormone CCK. No significant changes in plasma PYY3-36 levels occurred in the two eating conditions. These preliminary data demonstrate that in hedonic eating the peripheral hunger signal represented by ghrelin secretion is enhanced while the satiety signal of CCK production is decreased. This could be responsible for the persistence of peripheral cues allowing a continued eating as well as for the activation of endogenous reward mechanisms, which can drive food consumption in spite of no energy need, only for reward.
Authors:
Palmiero Monteleone; Pasquale Scognamiglio; Alessio Maria Monteleone; Donato Perillo; Benedetta Canestrelli; Mario Maj
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-08
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  38     ISSN:  1873-3360     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-06-14     Completed Date:  2014-01-31     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1435-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism
Cholecystokinin / blood*
Eating / physiology*
Energy Intake / physiology
Female
Ghrelin / blood*
Humans
Male
Peptide Fragments / blood*
Peptide YY / blood*
Reward*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Ghrelin; 0/Peptide Fragments; 106388-42-5/Peptide YY; 123583-37-9/peptide YY (3-36); 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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