| Gastroduodenal ulcerations in patients receiving selective hepatic artery infusion chemotherapy. | |
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MedLine Citation:
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PMID: 3159256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ninety-three patients with liver metastases underwent selective hepatic arterial infusion of chemotherapeutic agents through a surgically implanted hepatic artery catheter and pump. Fourteen patients who developed upper gastrointestinal symptoms at some time during the course of treatment were found to have gastroduodenal disease endoscopically. The severity of symptoms did not necessarily correlate with severity of endoscopic findings. There was no temporal relation between 5-fluoro-2'-deoxuridine infusion and symptoms; however, with mitomycin C, symptoms worsened in five of eight patients within 2 wk of the initial injection. Patients who received mitomycin C had more severe endoscopic findings and two of the 14 patients required partial or total gastrectomy. When biodegradable starch microspheres were coadministered with mitomycin C this was not associated with a higher incidence of gastroduodenal disease. The early experience with therapy using this system has been associated with a significant incidence of upper gastrointestinal symptoms. The presence of gastrointestinal symptoms in such patients should alert one to potentially serious disease. |
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Authors:
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J J Wells; T T Nostrant; J A Wilson; J W Gyves |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 80 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-07-09 Completed Date: 1985-07-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 425-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Breast Neoplasms / complications Female Floxuridine / adverse effects*, therapeutic use Gastroscopy Humans Infusions, Intra-Arterial Liver Neoplasms / drug therapy*, secondary Male Microspheres Middle Aged Mitomycin Mitomycins / adverse effects*, therapeutic use Peptic Ulcer / chemically induced*, diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Mitomycins; 50-07-7/Mitomycin; 50-91-9/Floxuridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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