| Gastrodin decreases immunoreactivities of gamma-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils. | |
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MedLine Citation:
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PMID: 12548709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastrodin is one of the natural compound isolated from Gastrodia elata and has known anticonvulsant effects, although the exact pharmacological principles of this natural compound and its effects on other aspects of gamma-aminobutyric acid (GABA) metabolism in vivo have not been explored. Therefore, in the present study, the effects of gastrodin on GABA metabolism in the gerbil hippocampus were examined, in an effort to identify the antiepileptic characteristics of this substance. Gastrodin reduced the seizure score in the treated group, although the immunoreactivities of GABA synthetic enzymes and GABA transporters were unaltered in gastrodin-treated animals. Interestingly, in the gastrodin-treated group, GABA transaminase (GABA-T) immunoreactivity in the hippocampus, particularly in neurons, was significantly decreased. In the gastrodin-treated group, both succinic semialdehyde dehydrogenase (SSADH) and succinic semialdehyde reductase (SSAR) immunoreactivities in the hippocampus was also decreased significantly, which stood in contrast to the nontreated group, in which strong SSADH and SSAR immunoreactivities were detected. From the neuroanatomical viewpoint, these findings suggest that gastrodin may cause the elevation of GABA concentration by inhibiting the GABA shunt. |
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Authors:
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Sung-Jin An; Seung-Kook Park; In Koo Hwang; Soo Young Choi; Sang Kook Kim; Oh-Shin Kwon; Sung Je Jung; Nam-In Baek; Hyeon Yong Lee; Moo Ho Won; Tae-Cheon Kang |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroscience research Volume: 71 ISSN: 0360-4012 ISO Abbreviation: J. Neurosci. Res. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-27 Completed Date: 2003-04-01 Revised Date: 2007-10-24 |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: United States |
Other Details:
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Languages: eng Pagination: 534-43 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Wiley-Liss, Inc. |
Affiliation:
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Department of Anatomy, College of Medicine, Hallym University, Chunchon, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzyl Alcohols* Gerbillinae Glucosides / pharmacology*, therapeutic use Glutamate Decarboxylase / analysis, metabolism Hippocampus / chemistry, drug effects*, enzymology Immunochemistry / methods Isoenzymes / analysis, metabolism Seizures / drug therapy, enzymology* gamma-Aminobutyric Acid / analysis, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Benzyl Alcohols; 0/Glucosides; 0/Isoenzymes; 56-12-2/gamma-Aminobutyric Acid; 62499-27-8/gastrodin; EC 4.1.1.15/Glutamate Decarboxylase; EC 4.1.1.15/glutamate decarboxylase 1; EC 4.1.1.15/glutamate decarboxylase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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