Document Detail


Gastro-allergic anisakiasis as a consequence of simultaneous primary and secondary immune response.
MedLine Citation:
PMID:  12060318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gastro-allergic anisakiasis has been reported as an entity in which an acute parasitism by Anisakis simplex is accompanied by an immunoglobulin (Ig)E-mediated systemic allergic reaction. Serum samples were obtained from 24 patients within 24 h after the onset of symptoms (day 0) and after 1 month (day 30) and in 13 patients after 6 months. Total IgE was assessed by the Imx method. Specific IgE was assessed by CAP-FEIA. Specific IgM, IgG, IgG4 and IgA antibodies were assessed by enzyme-linked immunosorbent assay against crude extract (CE) and excretory-secretory products (ESP). IgE immunoblotting (IB) was directed against CE or ESP (day 0 and day 30). We found a rise of total IgE, specific IgE, number of bands in IgE-IB, IgG and IgG4 between day 0 and day 30 with a fall to near basal levels after 6 months. IgM levels were highest at day 0, falling over the next 6 months and IgA levels remained almost unchanged. Correlation studies revealed a parallel stimulation of nearly all Ig isotypes, except IgM anti-ESP, whose antibody levels correlated negatively with specific IgG levels. We found an extension of the IgE antibody repertoire in IB. We conclude that the allergic IgE-mediated reaction in the course of gastro-allergic anisakiasis involves a parallel secondary Th2 type memory response and a primary immunologic stimulation of both Th2 and Th1 lymphocyte subsets against previously unrecognized antigens.
Authors:
Alvaro Daschner; Carmen Cuéllar; Sofia Sánchez-Pastor; Cristina-Yolanda Pascual; Manuel Martín-Esteban
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Parasite immunology     Volume:  24     ISSN:  0141-9838     ISO Abbreviation:  Parasite Immunol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-12     Completed Date:  2002-12-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  243-51     Citation Subset:  IM    
Affiliation:
Seccion de Alergia, Hospital Universitario La Princesa, C/Diego de Leon 62, E-28006, Madrid, Spain. adaschmer@meditex.es
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MeSH Terms
Descriptor/Qualifier:
Animals
Anisakiasis / immunology*
Anisakis / immunology
Antibodies, Helminth / biosynthesis*
Fishes / parasitology
Hypersensitivity / immunology*
Immunoblotting
Immunoglobulin A / analysis
Immunoglobulin E / analysis
Immunoglobulin G / analysis
Immunoglobulin Isotypes
Immunoglobulin M / analysis
Immunoglobulins / analysis*,  classification
Kinetics
Stomach / anatomy & histology,  parasitology
Chemical
Reg. No./Substance:
0/Antibodies, Helminth; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin Isotypes; 0/Immunoglobulin M; 0/Immunoglobulins; 37341-29-0/Immunoglobulin E

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