| Gastrin, somatostatin and oxytocin levels in patients with functional disorders of the gastrointestinal tract and their response to feeding and interaction. | |
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MedLine Citation:
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PMID: 1681097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-four individuals with functional disorders of the gastrointestinal tract participated in the study. Symptoms from the upper and lower gastrointestinal tract were recorded by means of a self-administered questionnaire before, 3 months and 3 yr after participation in group therapy. Blood was sampled from the patients while they were subjected to three different provocations (a friendly greeting, a food stimulus and a stress stimulus). Ten subjects without gastrointestinal symptoms participated in an identical experiment. Gastrin, somatostatin and oxytocin levels were measured with radioimmunoassay. Both gastrin and somatostatin levels were influenced by the provocations and by the greeting and the stress stimulus in particular. In principle, the controls tended to react with a parasympathetic response pattern following the interactive stimuli, whereas the individuals with functional disorders of the gastrointestinal tract reacted with an activation of the sympathetic nervous system. Somatostatin levels were significantly higher and oxytocin levels lower in patients than in controls and gastrin levels tended to be higher in patients than in controls. Most individuals reported both gastric as well as intestinal symptoms. Gastrin levels correlated positively with total symptom level and somatostatin levels with intestinal symptoms scores reported by the patients. |
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Authors:
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K Uvnäs-Moberg; I Arn; T Theorell; C O Jonsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of psychosomatic research Volume: 35 ISSN: 0022-3999 ISO Abbreviation: J Psychosom Res Publication Date: 1991 |
Date Detail:
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Created Date: 1991-11-21 Completed Date: 1991-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376333 Medline TA: J Psychosom Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 525-33 Citation Subset: IM |
Affiliation:
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Dept of Pharmacology, Karolinska Institute, Stockholm, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arousal / physiology* Eating / physiology* Female Follow-Up Studies Gastrins / blood* Gastrointestinal Diseases / blood*, psychology*, therapy Humans Male Middle Aged Oxytocin / blood* Psychophysiologic Disorders / blood*, psychology*, therapy Psychotherapy, Group* Somatostatin / blood* Vagus Nerve / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 50-56-6/Oxytocin; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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